VIII. B, 6 Gibson: Proteoses and Fever 477 



and, in tubercular animals, show effects somewhat similar to 

 tuberculin.'^ 



Ott and Collmar " first noted that the introduction of proteoses 

 intravenously produces a considerable and immediate rise in 

 body temperature in rabbits. Matthes '^ found that the subcu- 

 taneous injections of proteoses (dentero-albumose of Neumeis- 

 ter) are more pyrogenic for tubercular than for sound animals. 

 Krehl,'" Krehl and Matthes,'" and Roily ^^^ report experiments in 

 which pyrexial effects from proteoses were obtained. When 

 prepared in the laboratory from protein material, however, the 

 proteoses are neither so uniformly pyrogenic nor so pronounced 

 in their effects as are the products of bacterial origin. Von 

 Behring," on the contrary, failed to observe any augmentation of 

 temperature as the result of injecting sterile proteose solutions, 

 Klemperer ^^ does not consider the causative factor of fever to 

 be proteose, but ascribes such effect to adherent impurities. 



Considerable emphasis was laid by Krehl and Matthes -' on the 

 occurrence of proteoses in the urine in both infections and aseptic 

 febrile conditions. Schultess ^" reached the same conclusion. 

 Morawicz and Dietschy -' have shown that the presence of proteo- 

 ses in the urine is by no means constant in fever. Subsequently, 

 Krehl retracted his ideas in regard to proteose fever.^* 



Other substances, injected or formed in the course of interme- 

 diate metabolism, have been reported as possessing more or less 

 pyrogenic action. These include boiled or unheated enzymes;-' 

 various proteins, amines, amino-acids, and sodium salts ;^*' pu- 



" Krehl, Arch. f. exp. Path. u. Pharm. (1895), 35, 222; Krehl und Mat- 

 thes, ibid. (1895), 36, 437; Centanni, Deutsche mcd. Wochenschr. (1894), 

 20, 148, 176; Voges, Zeitschr. f. Hyg. u. Infectionskrankh. (1894), 17, 474; 

 Martin, Goulstonian lectures, Brit. Mcd. .Journ. (1892), 1, 641; Wood, 

 Lancet (1896), 1, 980. 



"Journ. Physiol. (1887), 8, 218. 



^' Deutsches Arch. f. klin. Med. (1894), 54, 391. 



"Arch. f. exp. Path. u. Pharm. (1895), 35, 222. 



''Ibid. (1896), 36, 437; ibid. (1898), 40, 434. 



'" Deutsches Arch. f. klin. Med. (1902), 78, 250. 



'" Lehrbuch der allgemeinen Therapie, von Eulenberg und Samuel (1898- 

 99), 3, 991. 



'° Naturforscherversanimlung, Kassel (1903), 2, 67. 



"Arch. f. exp. Path. u. Pharm. (1898), 40, 430. 



" Deutsches Arch. f. klin. Med. (1897), 58, 325; ibid. (1898), 60, 55. 



"Arch, f. exp. Path. u. Pharm. (1905), 54, 88. 



"Cf. MacCallum, The Harvey Lectures. New York (1908-09), 55. 



"Ott and Collmar, loc. cit.; Krehl, loe. cit.; Edelberg, Arch. f. exp. Path, 

 u. Pharm. (1880), 12, 283. 



" Krehl, loc. cit. 



