478 The Philippine Journal of Science 



1913 



rines and their precursors;-" ammonia -» and organic acids ;2" 

 and sodium-halogen salts.-^^' 



Friedberger and Mita seize upon the possibility of the forma- 

 tion of pyrogenic proteoses to explain the temperature rise in 

 sensitized guinea pigs referred to above. Thus they say: 



Wir miissen annehmen, dass die gewohnliche Anaphylaxis dadurch zu- 

 stande kommt, dass aus dem parenteral eingefiihrten Eiweiss Spaltprodukte 

 entstehen, die todlich wirken, und ebenso ist es bei der Darstellung des 

 Anaphylatoxins in vitro. 



Genau wie wir nun hier durch Verringerung der eingefiihrten Menge 

 zuerst statt Tod Temperatursturz, dann nach einer Dosis, die die Tempe- 

 ratur scheinbar unbeeinflusst lasst, Temperatursteigerung haben, bis wir 

 schliesslich an einen unteren Schwellenwert kommen, genau so verhalt es 

 sich wenn in den praparierten Organismus nicht fertiges Anaphylatoxin, 

 sondern Eiweiss in untertodlicher Dosis eingefiihrt wird. 



It is inconceivable to me that 0.0000005 cubic centimeter of 

 sheep's serum, as used in some of Friedberger and Mita's exper- 

 iments, would yield sufficient proteose to produce pyrogenic 

 effects, even though the animals be highly sensitized. 



Further evidence, however, for a febrile reaction in anaphy- 

 laxis of causal relation to proteoses is given in a recent paper 

 by E. Zunz.''! This investigator studied the active and passive 

 anaphylaxis for peptic proteoses, prepared from fibrin accord- 

 ing to the methods of Adler, of Haslam, and of Pick, and for the 

 Siegfried peptone from the same material. He finds that, if a 

 third intravenous injection of heteroalbumose or protalbumose 

 is given eight, twenty-five, or thirty days subsequent to the pro- 

 duction of the anaphylactic shock, a rise of from 1° to 2° in the 

 rectal temperature may be observed (although no effects were ob- 

 tained for longer periods than thirty days). 



The identity of "peptone" intoxication with anaphylactic shock 

 has recently been questioned. Bordet believes that any such 

 conclusion "is so far very unprecise." And, in as much as he *- 

 has shown that anaphylatoxin may be developed in vitro from 



"Burian und Schur, Arch. f. d. ges. Physiol, Bonn (1901), 87, 239; 

 Mandel, Am. Joiim. Physiol. (1904), 10, 453. 



"Erben, Zeifschr. f. Heilk. (1904), 25, 33. 



"' Regnard, Combustions-Respiration (1879); Geppert, Zeitschr. f. klin. 

 Med. (1880), 2, 356; Minkowski, Arch. f. exp. Path. u. Pharm. (1885), 

 19, 209; Kraus, Zeitschr. f. Heilk. (1889), 10, 1. 



"'Meyer, Deutsche vied. Wochenschr. (1909), 35, 194; Friberger, Arch, 

 f. Kinderheilk. (1910), 53, 17; Schloss, Biochcm. Zeitschr. (1909), 18, 14; 

 and others. 



" Loc cit. 



" Loc cit. 



