VIII. B. fi 



Gibson: Proteoses and Fever 



483 



Table III. — Experiment 22. Edestinoses {alcohol soluble). 



Guinea pis ; female ; weight, 600 grams. Received a subcutaneous injection of 4.5 cubic centi- 

 meters of physiological salt solution at 10 a. m. on April 27 and on April 28, and of 0.4 gram 

 of edestinoses at 12.S0 p. m. on April 29. 



Date. 



Temperature. 



Observa- 

 tions. 



Remarks. 



Average. 



Range of 

 variation. 



Apr. 25 — -- 



°C. 

 39.2 

 39.1 

 38.9 

 38.9 

 38.5 

 38.4 

 38.1 

 88.9 



°C. 



38.8 to 39.4 



38. 9 to 39. 3 

 38.9 to 39.0 



38.6 to 39.2 

 38. 5 to 38. 6 

 38. 1 to 38. 8 



37.7 to 38.4 

 38.5 to 39.2 



39.0 



7 

 7 

 2 

 7 

 2 



4 

 7 

 1 



No injection. 



Do. 

 Before injection. 

 Saline, 4. 6 cc. 

 Before injection. 

 Saline, 4. 5 cc. 

 Before injection. 

 Proteoses, 0. 4 gm. 

 No injection. 



26 



27 



27 -. 



28 



28. 



29 



29 



30 







When compared with the saline injection on April 27 and with the 

 observations on April 25 and 26, it does not appear that the proteoses are 

 pyrexial. 



Table IV. — Experhnent 23. Caseoaes (alcohol soluble) . 



Guinea pig ; male ; weight, 440 grams. Injections of 4.5 cubic centimeters of physiological salt 

 solution at 10 a. m. on April 27 and on April 28, and of 0.46 gram of caseoses at 12.80 p. m. 

 on April 29. 



Date. 



Temperature. 



Observa- 

 tions. 



Remarks. 



Average. 



Range of 

 variation. 



Apr.25 



26 - 



39.4 

 39.1 

 38.6 

 39.1 

 37.9 

 38.6 

 38.4 

 38.8 



°C. 



38.7 to 39.8 

 38. 6 to 39. 8 

 38. 6 to 38. 6 

 38. 2 to 40. 



37.8 to 38.0 



37.9 to 39.0 

 37. 6 to 39. 

 38. 2 to 39. 7 



39.1 



7 

 7 



6 

 2 

 6 



4 



7 



1 



No injection. 



Do. 

 Before injection. 

 Saline, 4.5 cc. 

 Before injection. 

 Saline, 4. 5 cc. 

 Before injection. 

 Proteose, 0. 45 gm. 

 No injection. 



27 



27 



28 - 



28 — 



29 



29 



30 







The temperature changes in this guinea pig are very abrupt and erratic. 

 A temperature rise (April 27) following tHte injection of the physiological 

 salt solution is more marked than that noted subsequent to the adminis- 

 tration of the proteose; similarly, higher normals were obtained for April 

 25 and 26, when no injections were made. 



