484 



The Philippine Journal of Science 



1913 



Table V. — Experiment Si. Caseoses. 



Guinea pig; male; weight, 570 grams. Subcutaneous injection of 4.5 cubic centimeters of 

 physiological salt solution at 10 a. m. on April 27 and at 12 a. m. on April 28, and of 0.45 

 trram of caseoses in 4.6 cubic centimeters of salt solution at 12.30 p. m. on April 29. 



Date. 



Temperature. 



Observa- 

 tions. 



Remarks. 



Average. 



Range of 

 variation. 



Apr. 25 _ 



°C. 

 39.1 

 38.9 

 38.7 

 38.9 

 38.5 

 38.9 

 38.6 

 38.9 



38.0to39.6 [ 7 

 38. 6 to 39. 5 ! 7 

 38.6to38.8i 2 

 38.4to39.4i 7 

 38.3to38.8| 2 

 38.3to39.6j 7 

 38.0to39.2 I 4 

 38. to 40. 7 

 38.4 1 



No injection. 



Do. 

 Before injection. 

 Saline, 4. 6 cc. 

 Before injection. 

 Saline, 4. 5 cc. 

 Before injection. 

 Proteose, 0.46 gm. 

 No injection. 



26 



27 



27 



28 



28 



29... 



29 



30 











While in this experiment the caseoses produce a transient temperature 

 rise to a figure slightly higher than any of the control observations, the 

 pyrexial effects are not especially convincing. The control saline injections 

 would possibly be called somewhat pyrogenic if the normal observations 

 on the two days preceding were not in existence. As it is, the form of 

 the curve of the variations on the two saline injection days is strikingly 

 similar to the proteose day. The experiment demonstrates in a striking 

 degree the danger of the misinterpretation of temperature observations in 

 which the initial readings are taken as the normal for the guinea pig. 



Table VI. — Experiment 25. Edestinoses. 



Guinea pig ; male ; weight, 440 grams. Injections of 4.5 cubic centimeters of physiological salt 

 solution at 10 a. m. on April 27 and 28, and of 0.4 gram of edestinoses (in 4 cubic centi- 

 meters of salt solution at 12.30 p.m. on April 29. 



Apr. 25 . 

 26- 

 27. 

 27. 

 28. 

 28. 

 29. 

 29. 

 30. 



Date. 



Temperature. 



Average. 



°C. 

 39.4 

 38.9 

 38.9 

 38.7 

 38.1 

 38.6 

 38.5 

 39.*0 



Range of 

 variation. 



°C. 

 39. to 



38. 4 to 



38.3 to 

 37. 9 to 

 38. Ito 



38. 4 to 

 38. to 



40.0 

 39.3 

 38.9 

 39.0 

 38.4 

 38.9 

 38.6 

 39.7 

 38.4 





Observa- 

 tions. 



Remarks. 



No injection. 



Do. 

 Before injection. 

 Saline, 4. 5 cc. 

 Before injection. 

 Saline, 4. 5 cc. 

 Before injection, 

 Proteoses, 4. 5 grams. 

 No injection. 



The control injection records in this experiment show less variation than 

 do the series of readings on the two previous normal days. The sudden 

 jump of the record to 39 ".7 within two hours of the proteose injection is 



