VIII, B, K 



Gibson: Proteoses and Fever 



485 



of interest. Higher figures, however, were obtained on the first normal 

 control day, although not subsequently. Any pyrogenic effect, if manifested 

 at all, in this experiment, must be interpreted as such from a consideration 

 of the control saline injection figures alone. 



Table WU.— Experiment 20. Edestinoses (alcohol noluble). 



Guinea pig; male; weight, 650 grams. Injection of 4 cubic centimeters of physiological salt 

 solution at 10 a. m. on April 27 and 28, and of 0.4 gram of edestinoses (in 4 cubic centi- 

 meters of saline) at 12.30 p. m. on April 29. 



Date. 



Temperature. 



Observa- 

 tions. 



Remarks. 



Average. 



Range of 

 variation. 



• Apr 25 - 



°C. 

 39.3 

 38.8 

 38.8 

 38.8 

 38.2 

 38.6 

 38.7 

 •39.5 



°C. 

 38. 9 to 39. 6 

 38.7 to 39.0 

 38. 7 to 38. 9 



38. 4 to 39. 

 38. 2 to 38. 2 

 38.2 to 39.2 



38. 5 to 38. 8 

 38.5 to 40.2 



38.4 



7 

 7 

 2 

 7 

 2 

 7 

 4 

 7 

 1 



No injection. 



Do. 

 Before injection. 

 Saline, 4 cc. 

 Before injection. 

 Saline, 4 cc. 

 Before injection. 

 Proteoses, 0.4 Km. 

 No injection. 



26 -- --- 



27 



27 



28 



28 - — 



29- -- - - 



29 



30 







' , ,. 





The readings on the proteose day undoubtedly show a febrile reaction. 

 Table VIII. — Experiment ill. Edestinoses. 



Guinea pig; female; weight, 600 grams; used previously in experiment 22. Injections of h 

 cubic centimeters of physiological salt solution at 11 a. m. on May 4, and of 0.6 gram of 

 proteoses in 6 cubic centimeters of salt solution at 11 a. m. on May 5. 



Date. 

 May 2 



1 

 Temperature. 



Observa- 

 tions. 



Remarks. 



Average. 



Range of 

 variation. 



°C. 

 38.3 

 38.0 

 38.1 

 38.5 

 38.6 



•38.7 



°C. 

 38. 1 to 38. 8 



37. 7 to 38. 4 

 37. 9 to 38. 3 

 38. 3 to 38. 8 



37. 8 to 38. 2 

 36.1 to 39. 2 



38.5 



7 

 7 

 3 

 6 



9 

 1 



No injection. 



Do. 

 Before injection. 

 Saline, 5 cc. 

 Before injection. 

 Proteoses, 0. 5 gm. 

 No injection. 



3 



4 



4 



5 - 



6 



6 







1 



" Omitting the one subnormal reading. 



A rise to 39°. 2 following the characteristic fall after the edestinose 

 injection suggests some slight influence exerted by the proteoses; this rise, 

 however, is so little marked that any pyrogenic effect is very doubtful. It 

 may be due to the extra handling of the animal, for a larger number of 

 readings were taken on this day than during the control periods. 



