viii. B. tt Gibson: Proteoses and Fever 491 



Table XXIII. — Summary of experivients 46 to 56 inclusive. 



Proteose preparation. 



^I^*y Result. ! 

 ments. 



Control physiological saline 



3 No fever. 1 



1 Control — no injection- ._ _ . _._. 



1 

 3 



Do. 1 



Do. 

 No fever. Tempei-ature dropped 

 below normal, and remained low. 

 No fever. 



Do. 

 Animal died as result of injection. i 



Edeetinosee _ _. _ 



Edestinoses (alcohol soluble) .. 



1 



1 

 1 

 1 



Caseoses 



Caseoses (alcohol soluble) 



Fibrinoees 



In the experiments with rabbits, the slight rise in temperature with 

 some of the proteoses is insignificant and is amply accounted for by the 

 control days and the saline-injected rabbits. In the earlier rabbit experi- 

 ments, conducted at the Sheffield Laboratory, the results were not so 

 uniformly nonpyrogenic. I believe that facility in handling the rabbits, 

 gained from experience in the previous work, has been a considerable 

 factor in promoting the uniformity of the experimental results in this 

 last series. 



From the evidence presente<3, then, it would seem that the prir 

 mary cleavage products of pepsin-hydrochloric acid digestion, 

 when prepared without drastic treatment, from purified and 

 well-characterized proteins, never have more than a slight pyro- 

 genic effect when injected subcutaneously into rabbits and 

 guinea pigs. Any temperature rise, if present, is insufficiently 

 pronounced to permit a direct inciting role to be ascribed to 

 such proteoses in the production of the severe naturally 

 occurring fevers. 



