900 SOCIÉl'É DE BIOLOGIE 



It is seen in table 5 that the best results were obtained in the séries 

 in which the glucose mixture was injected. The animais treated with 

 the British Committee solution, though, did almost as well, while the 

 animais treated with the carbonate mixture, if anything, did worse 

 than the untreated animais. The last resuit becomes especially clear 

 when the number of one day deaths of ail of the séries are compared. 

 Evidently the carbonate mixture hastens death. It cannot, however, be 

 concluded unequivocally that it is the carbonate of the mixture that 

 exerts this deleterious action, though this is indicated by comparison 

 with the results atlained with the glucose mixture, which like the car- 

 bonate mixture, contains 25 p. 100 acacia, but glucose in place of the 

 isomotic alkali. The acacia in the carbonate mixture, how3ver, is in 

 the form of the sodium sait, in the glucose mixture in the form of the 

 calcium sait; and it is possible either that sodium acacia is harmful, 

 which we do not believe is the case, or that calcium acacia is bénéficiai, 

 which we hâve been unable to demonstrate. 



Tables i to 4 show that in each séries the average initial pressure of 

 the cases that recover is strikingly lower than of the cases that die. We 

 cannot in this report attempt an analysis of this observation. We men- 

 tion it for the purpose of calling attention to the fact that the animais of 

 the glucose séries that lived had higher initial pressures than the similar 

 groups in the other séries. Presumably, therefore, the séries that 

 présents the best results, had the most unfavorable prognosis. 



It is also possible that animais depleted of water, as are ours by the 

 purging and vomiling induced by the morphia, and subsequenlly as a 

 resuit of the diarrhoea they of ten hâve, are not the best subjects for 

 treatment by hypertonic solutions. 



AU of Ihe treatments more than restore, and satisfactorily maintain, 

 the blood volume as determined by the haemoglobin percentage; they 

 ail raise the artcrial pressure, the glucose and carbonate mixtures more, 

 apparently, than the British Commiltee solution ; and the glucose mix- 

 ture seems to hâve the most marked efîect upon the puise amplitude. 

 The British Committee solution presumably is approximately isomotic 

 with the coUoids and crystalloids of the blood, and has the same visco- 

 sity as the blood. We hâve determined that when 5 p. 100 Na^Go" is 

 given in place of the NalICO' of the carbonate mixture, it raises the 

 alkali reserve, as estimated in volume per cent of CO^ in the plasma of 

 arterial blood, from the level of about20 before treatment, to about 50. 

 The bicarbonate, as given in the carbonate mixture, would therefore 

 efîect somewhat over just about half of this increase, the Brilish Com- 

 mittee solution something more than one fourth, while the glucose mix- 

 ure would havc no efîect upon the reserve except perhaps to diminish 

 it" through the slight acidity of th3 acacia. We hâve not determined 

 whether it afîects it indirectly. 



