54 OHNO. 



B being entirely distinct from that of A' and B', and if the quantities 

 of A and A' and also those of B and B' are not equal, then the curve 

 graphically representing the agglutination phenomena of such a serum is 

 composed of four straight lines intersecting at three points and having 

 two apices like a mountain with two peaks. Such a serum can be termed 

 "poly-apical," in contradistinction to one having only one apex, which 

 would consequently be called a "niono-apex-serum." With the former 

 it is difficult to estimate the value of agglutinin and agglutinoid from 

 the formula 



. G — m 



A=CM 

 B = Cm 



M — ?n 

 M — G 

 M — m 



with known values of m, G, and M, because there are two factors for G. 

 For this reason I have used only mono-apex-serum, either obtained as such 

 directly from animals or man or by a modification of a poly-apical variety. 

 It is very interesting to discuss the character of poly-apical sera, but 

 their consideration depends rather upon the relations between the bac- 

 terial receptors and amboceptors, and consequently I will leave this topic 

 for another paper which will be especially devoted to this problem. 



At the result of this series of experiments I am of the opinion that 

 the union of agglutinin and agglutinable substance is not analogous to 

 the fixation of dye by a tissue, as Bordet considers it to be, but I believe 

 it to be a chemical reaction, as is maintained by Ehrlich. 



The detailed report, of which this is a summary, will shortly be 

 published in another journal. 



