TUBERCULO-TOXOIDIN AND IMMUNIZATION SERUM.' 



By T, Ishigami.- 



One of the great misfortunes of mankind is that as yet there is no 

 perfect scientific method of successfully combating man's stubborn enemy, 

 tuberculosis. In my belief, the only rational and promising cure for 

 this disease in modern thereapy is the bacteriologic one. 



As Koch's preparations prove efficacious on incipient tuberculous pa- 

 tients in many instances only when administered with a careful avoidance 

 of the reaction, the lirst and most natural step to be taken in our study 

 of the cure is one toward methods of obviating the reaction. After 

 continuous investigations for more than ten years, I have succeeded in 

 preparing two remedial agents of comparatively great efficacy and free 

 from any detrimental reaction. 



(1) The first is a chemical preparation from tubercle bacilli and is 

 applicable to incipient and feveiiess patients. 



(2) The other is an immune serum and is applicable chiefly to 

 patients in an advanced stage of the disease. 



I introduced these in the belief, based on my own experience of several 

 years, that they were harmless and effective, although not absolutely 

 infallible remedies for tuberculosis. I have since received the corrobora- 

 tion of many practitioners who recognize their efficacy and harmlessness. 

 In this paper I will attempt to describe them briefly. 



TUBERCULO-TOXOIDIN". 



This preparation is made by chemically dissolving the tubercle bacilli 

 and modifying their toxic property, thus eliminating the reaction which 

 is the common detriment of all other preparations made from tubercle 

 bacilli. 



According to the modern theory of immunization, a strong immunity 

 can not be attained without employing strong toxin. Therefore, the 

 question will naturally suggest itself as to whether immunization can 

 be imparted by employing a chemically transformed and harmless toxin. 

 My honored masters, Professors Kitasato and Behring, succeeded in 



1 Read at the Fifth Annual Meeting of the Philippine Islands Medical As- 

 sociation, Manila, P. I., February 28, 1908. 



2 Director of the Ishigami Institute for Infectious Diseases, Osaka, Japan. 



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