456 MUSGEAVE, CLEGG, AND POLK. 



with extensive adhesions of the mesentery to the abdominal wall. On separating 

 the adhesions, or on section through them, numerous sinusses are exposed; these 

 hold a thick, viscid, pus-like substance containing numerous small grayish-white 

 granules composed principally of Streptoihrvc. 



Monkeys numbered 366-b, 3633, 3622 were inoculated in a similar manner to 

 monkey No. 3GC5 and the lesions produced were in all essentials similar to those 

 found in that animal. 



Foulerton's strain of 8. eppingeri. 



Monkey No. 3725 was inoculated in the abdominal cavity with one loop of a 

 ten days' culture and the lesions produced are similar to those found in animals 

 inoculated with <S. eppingeri of the original strain. 



S. madurw. 



Monkey So. 385Jf was inoculated by opening the abdominal cavity and burying 

 a loop of the material from a two weeks' culture of Strong's strain of the 

 organism. Ten days later the animal presented a distended abdomen with a 

 marked tympanites and was killed on this date. Autopsy shows numerous miliary 

 tubercle-like processes in the omentum and mesentery and adhesions surrounding 

 the inoculated material. The adhesions are easily separated and show small, 

 pinkish-white granules adhering to the mesentery. 



Rabbits and guinea pigs inoculated subeutaneously, intravenously, and intra- 

 peritoneally with this organism gave negative results. 



Monkey So. 3S56 was inoculated in the abdominal cavity with one loop of a 

 two weeks' culture of Fullerton's strain of this organism and killed two weeks 

 later. Autopsy shows a small, tumor-like mass made up largely of adhesions 

 confined to the coils of the intestine, omentum, and abdominal wall. On section 

 the tumor shows several small abscesses from which can be expressed a thick 

 pus containing small, white granules composed almost entirely of the organisms. 

 The latter are present in large numbers. 



Monkey No. 372Jf was inoculated in a manner similar to the above with 

 negative results. 



Guinea pig No. 3856 was inoculated into the abdominal cavity with one loop 

 of a two weeks' culture and killed after 10 days. Autopsy shows slight adhesions 

 of the omentum to the abdominal wall and intestine, but no other lesions are 

 present. - . - j 



Subcutaneous and intravenous inoculations of monkeys, rabbits, and guinea 

 pigs gave negative results in every ease. 



Monkeys numbered 3719, 3627, 366S were inoculated with one loop of a two 

 weeks' culture of Vincent's original strain of this organism. The inoculations 

 were made subeutaneously and intraperitoneally and in no instance were progres- 

 sive lesions produced. 



Guinea pigs and rabbits inoculated subeutaneously, intravenously, and by in- 

 traperitoneal injections also gave negative results. 



Actinomyces (from the Pasteur Institute) : 



Monkey No. 3S6.'i was inoculated into the abdominal cavity with one loop of 

 a two weeks' culture. The animal died three weeks later. Autopsy shows small 

 abscesses in the abdominal wall at the site of inoculation and numerous miliary, 

 tubercle-like granules in the omentum and mesentery. The pus from the abscesses 

 contains many minute, hard, black granules which by microscopic examination 

 are seen to be made up of a net-work of myeelia and transformation products 

 of the microorganism. 



Monkeys numbered 3622 and 3623 were inoculated in a similar manner and 

 presented similar lesions to the above. Intravenous, subcutaneous, and intraperi- 

 toneal inoculation of rabbits and guinea pigs gave negative results in each case. 



