466 MUSGRAVE, CLEGG, AND POLK. 



from the lesions. Cultures at first only grew in bouillon, but gradually growth 

 on other media was successful. The anaerobic tendencies of his organism were 

 changed so that it grew aerobieally after a considerable time on artificial media. 

 This organism produced lesions in the eyes of rabbits. Silberschmidt (Ztschr. 

 f. Hyg. u. Infectionskrankh.' (1901), 37, 345) studied eight cases of Streptothrix 

 infections in man. He cultivated the organism and believed he had isolated 

 three different species. In six of his eight cases the organisms closely resembled 

 those of Wolff and Israel. The others more closely approximate Bostroem's 

 organism. Jelenewski (Ref. Baumgarten's Jahresb. (1901), 17, 495) studied 

 fifty cases of actinomycosis occurring in the mouths of animals. He cultivated 

 the fungus first with B. sxibtilis. Later he obtained pure cultures both aerobieally 

 and anaerobically. Cultures of the organisms were pathogenic for calves, but not 

 for rabbits and guinea pigs. The author concluded that his Streptothrix was a 

 new species, basing his decision upon both its cultural and pathogenic properties. 



Foulerton and Jones (Tr. Path. Soc. (1902), 53, 56) studied the group 

 extensively and described some new species. The tentative classification b}' these 

 authors was the most satisfactory which had been made up to the time of its 

 publication. 



They also cultivated a Strej>tothrix ( (ibid), 75, 93) which they believed to be 

 the cause of the disease, from a conjunctivitis and keratitis in a twelve year old 

 girl. The organism was Gram positive, but not acid- fast; a facultative aerobe 

 growing on all media. It was not pathogenic for rabbits, guinea pigs, or white 

 mice. The same authors (ibid, 100) isolated a Streptothrix from "a case of 

 pulmonary infection in a woman." This organism was Gram positive, not acid- 

 fast, grew on the usual laboratory media, and was not pathogenic for rabbits. 

 MacCallum (Centralbl. f. Bakt., etc. orig. (1902), 31, 529) cultivated a Strep- 

 tothrix which he considered to be identical with that of Eppinger from the 

 peritoneal exudate in the body of a child dead of subacute purulent peritonitis 

 which followed a surgical operation for relief of stricture of the oesophagus. 

 Birt and Leishman (Journ. Hyg. (1902), 2, 120) studied a Streptothrix which 

 was obtained from a fatal human case. Empyema, pericarditis, and "cirrhotic 

 nodules in the lungs" were present at autopsy. The organism was isolated from 

 the pleura, pericardium, and lung. It was Gram positive and acid-fast and 

 showed strong aerobic tendencies. It grew on the majority of media, producing 

 a coral-pink color. This organism was pathogenic for guinea pigs and is probabty 

 identical with Eppinger's Streptothrix. Sehukewitseh (Ref. Jahresb. d. ges. Med. 

 (1902), 1, 711) cultivated a Streptothrix somewhat resembling that of Wolff 

 and Israel from twenty-two out of twenty-five cases of human actinomycosis. 

 Von Baraez (Arch. f. klin. Chir. (1902), 68, 1050) reports on fifty-two cases of 

 actinomycosis. The article is a splendid monograph, but does not go extensively 

 into the question of the etiology of the disease. Welleminsky (Deutsche med. 

 Wchnsch. (1902), 28, Ver.-Beil. 196) cultivated a Streptothrix-like organism, 

 nonpathogenic for animals, from lesions in one ease. 



Trolldenier (Ztschr. f. Thiermed. (1903), n. s. 7, SI) reports a ease of acti- 

 nomycosis in a dog. He cultivated a Streptothrix which he considered to be a 

 new species from the lesions. The organism was pathogenic for mice and guinea 

 pigs, rabbits, dogs, and calves. Doepke (Munchener med. Wchnsch. (1903), 50, 

 II, 2245 ) studied several human cases and cultivated organisms which where 

 similar to that of Wolff and Israel. Lignieres and Spitz (Arch. d. parasitol. 

 (1903), 7, 428; Centralbl. f. Bakt., etc. (1904), 35, 294; 452) cultivated a 

 Streptothrix from a calf suffering from actinomycosis which they considered similar 

 to that of Wolff and Israel. The article by Horst (Ztschr. f. Heilk., Abt. f. path, 

 anat. (1903), 24, 157) is not available to us. 



