STEEPT0THE1C0SIS. 469 



the discussion in this paper. Gaminiti recognizes forty-one species based upon 

 his own work and a review of the literature. Manson's classification refers 

 particularly to mycetoma and has already been noticed. 



If we carefully study .the literature of species determination, it will 

 be found in greater part to be only of historic interest and value. The 

 work is generally too incomplete to be final for species determinations, 

 and in cases even the generic position of the described parasites is 

 doubtful. For this reason we have considered only the technical descrip- 

 tions of the organisms which have been cultivated and described with 

 sufficient accuracy and completeness to make them available for com- 

 parative purposes. Much of the work of the older writers was well 

 done when due consideration is given to the technique developed at the 

 time of publication, and this work should always be kept before us in 

 giving historical summaries. However, for purposes of further study 

 and for comparison, having in view the harmonizing of our ideas regard- 

 ing these infections, it seems to us that the following are the principal 

 publications regarding Streptotliricce,, which have been isolated from 

 pathologic lesions of man or animals. 



1. Nocard (1888); 2. Eppinger (1890); 3. Almquist (1890); 4. Bostroem 

 (1891); 5. Wolff and Israel (1891); 6. Hesse (1892); 7. Vincent (1894); 8. 

 Boyce and Surveyor (1894); 9. Aschoff (1895); 10. Du Bois Saint-Sevrin 

 (1895); 11. Sabrazes and Riviere (1894) (A and B) ; 12. Rullmann (1895); 

 13. Dor (1896); 14. Sawtschenko (1896); 15. Scheele and Petruschky (1897); 

 16. Bucholtz (1897); 17. Berestnew (1897); 18. Rullmann (1898); 19. Silbers- 

 chmidt (1899); 20. Brault (1899); 21. Gozzolino (1900); 22. Dean (1900); 

 23. Aoyoma and Miyamoto (1901) ; 24. Jelenewski (1901) ; 25. Foulerton (1902) 

 (3 or more species); 26. Trolldenier (1903); 27. Pinoy (1906). The work of 

 Musgrave and Clegg (1907) might also be included in this list. 



The twenty-eight species of varieties to be taken, from this list are 

 considered with due regard to the manner in which they are described 

 by the authors. It is certain that they do not all represent different 

 species and it is probable that some of the other organisms not included 

 do belong to new species. Many of the articles in the literature are 

 incomplete, and a careful study of such descriptions as are given 

 convinces us that not more than ten different species are represented in 

 the group. Several of the varieties may show slight morphologic and 

 biologic differences, but these are not sufficient to warrant their being 

 classed as separate species. 



GENEBAL DISCUSSION AND CONCLUSIONS. 



The subject of streptothricosis or nocardiosis becomes somewhat sim- 

 plified if the results of our own work are combined with those taken 

 from the literature, but we realize fully that after considering all pos- 

 sible evidence, points must still remain open for discussion, and complete 

 harmony regarding this subject can only be obtained by common adop- 

 tion of a somewhat arbitrary classification. 



