The Structure of Colored Blood- Corpuscles. 279 



found hsematoblasts increased whenever under physiological 

 or pathological conditions a reparation of blood occurs, e. g. 

 he found them more abundant in children than in adults, and 

 more abundant during menstruation, and after losses of blood, 

 also during reconvalescence after acute diseases. 1 



Netsvetzki reported 2 having found minute corpuscles 

 moving in all directions, as constant constituents of normal 

 human blood. [Although my observations as to the diversity 

 of size of colored blood-corpuscles refer to healthy blood, I 

 will not omit to mention here that Vanlair and Masius, 

 having, in the blood of a patient who had symptoms of in- 

 terstitial hepatitis, found a number of small globular cor- 

 puscles, gave them the name of microcytes, and called the 

 patient's disease " microcythasmia," which they considered 

 to be a peculiar alteration of the blood. 3 Cases of so- 

 called microcythemia have since been reported by Litten, 

 in a tuberculous individual; 4 by Osier in pernicious 

 anemia 5 ; and by Lepine and Qermont in cases of cancer 

 of the stomach. Soerensen distinguished in disease be- 

 tween Oligocythemia, in which the number of red blood- 

 corpuscles is diminished, Achroiocythemia, in which their 

 richness in coloring matter is diminished, and Microcythemia, 

 in which their size is diminished. In a case of chlorosis ob- 

 served by him, the average size of the colored corpuscles was 



(1) " Note sur 1' evolution des globules rouges dans le sang des vert6bres ovipares." 

 Oompt. rendus, torn. 85, No. 20, p. 907-909. " Sur devolution des globules rouges dans le' 

 sang des animaux superieurs (verteb. ovipares) Ibid., No. 27, p. 1285. 



(2) " Zur Histologic des Menschenblutes. Eleine sich nach alien Richtungen bin bewe- 

 gende Korpercnen als constante Bestandtbeile des normalen Menschenblutes " Central- 

 zeitung fur die Medicinischen Wissenschaften, 1873, No. 10. 



(3) De la Microcythemie, Bruxelles, 1871 ; 101 pp. 



(4) Aus der Klinik des Herrn Geh. Rath Prof. Frerichs " Ueber einige Veranderungen 

 rother Blutkbrperchen." Berliner Klinisohe Wochenschrift ; 1877, No. 1. 



(6) "Ueber die Entwickelung von Blutkorperchen in Knochenmark bei pernicioser Anee- 

 mie." Centralblatt fur die medicinischen Wissenschaften ; 1877, No. 28 ; 1878, No. 26. 



(6) " Note sur la presence temporaire dans le sang humain d'un grand nombre de globules 

 rouges tres petits (microcytes)." Gazette medicale de Faris ; 1877, No. 18, pp. 218 and 

 219 ; and " Note relative a l'influence des saignees sur l'apparition dans le sang humain d« 

 petits globules rouges (microcytes)." Id. No. 24, p. 296. 



