286 The Structure of Colored Blood- Corpuscles. 



Hiller^ refuted the supposition of Htiter (II. Deutscher Chir- 

 urgen Congress, April 18, 1873), that the stellate and thorn- 

 apple forms of red blood-corpuscles are due to immigration of 

 monads into the substance of the corpuscles. He found such 

 forms in blood during febrile and non-febrile diseases; they 

 were absent in some cases in which large quantities of monads 

 had been injected into the blood of animals ; and he observed 

 in many cases their development directly underthe microscope. 



Rommelaere, 7 ' observed in various diseases, changes ot 

 shape of the red blood corpuscles. 



Zandois,3 saw corpuscles assume, before their dissolution, 

 a spherical form with exceedingly fine points. 



Ebertf £ ditcher, b Fuchs, 6 and Schmidt,' 1 have reported va- 

 riations of the ordinary shape. The latter has also called at- 

 tention to the fact that human red blood-corpuscles seen in 

 exact profile, and closely examined, are represented by two 

 straight and parallel lines connected at their extremities by 

 two semicircular ones, and not showing merely their central 

 concavity as usually represented. 



The question whether or not colored blood-corpuscles possess 

 an investing membrane, has been much discussed. Ilewson, 

 who, as I have already stated, showed that these corpuscles 

 are not perforated, contended that the dark spot in the middle 

 believed by Torre to be a perforation, " is a solid particle 

 contained in a flat vesicle, whose middle only it fills, and 



(1) "Ueber die Veranderungen der rotten Blutkbrperchf.n nebst Bemerkungen iiber 

 Microcyten " rentralb'att f d.med Wiss 1^74 Nos. 21 25. 



(2) ' De Ja deformation des globules rouges du sai g " Bruxelles 1874. 47 pp. 



(3) ■• Aufldsung dtr rotten Blutzellen." < entralblatt f. d med. VViss. 1874 No 27. p. 419 



(4) • Ueber Kormveriinderungen der rotten I lutkbrperchen." Greifswald 1875. 



(5i ■ Ueber eiuipe Verauderungen welrhe die rotten Blutlibrpercben in Ext>avaFaten 

 erleiden." Virchow's Arcbiv, vol 6j, ^876;. p. 295-307. Also in other articles which I quote 

 in this review 



(6) • Beitrag zur Kenntnissdes Froschblutesund der Froschlymphe." Vir chow's A rchiv, 

 vol. 71, (1877) p. 78-1 7 



(7) " The structure of the colored Blood-corpuscles of Amphiuma tridactylum, the Frog 

 and Man." Journal of the Micr. Soc of London, May and July, 1878, pp. 66. 68, HO, etc. 



