296 The Strrudute of Colored Mood- Corpuscles. 



still more recently 1 by means of a concentrated alcoholic 

 solution of corrosive sublimate (methods of " hardening the 

 blood-corpuscles and then extracting the heematin from 

 them "). Freer, using reflected instead of transmitted light 

 (by means of Wales' Illuminator) affirmed 2 independently of 

 Bottcher, the existence of a nucleus in human blood ; and 

 Piper* seems very desirous to confirm Freer. Brandt, hav- 

 ino- 4 , in the red blood-corpuscles of living Sipun cuius, occa- 

 sionally found a nucleus, though usually there is none, 

 thought that perhaps the nuclei are unstable formations which 

 by slight influences are produced or made visible, and by 

 others are destroyed or made invisible ; on examining a drop 

 of blood from his finger, on which he had before pricking 

 placed a little fresh chicken albumen, he usually found in 

 many red corpuscles what he was inclined to interpret as 

 a central nucleus, in confirmation of the observations of 

 Bottcher 5 . More recently Stowell has written a communica- 

 tion to corroborate Bottcher 6 . And Strieker has expressed 

 the opinion that the nuclei of embryonal colored blood-cor- 

 puscles of mammals persist as circular thin disks ; he argues 

 that these "disks are so large that the body proper of the cor- 

 puscle appears on a surface view as only a narrow zone : and 

 that, therefore, except with high powers, the existence of a nu- 

 cleus is easily overlooked : and he asserts that, by means of ob- 

 jective No. 15, he has in the blood-corpuscles of man, dog, rab- 

 bit, and cat, seen the nucleus in both surface and profile views. 1 



(1) "Ueber die feineren Structurverhiiltnisse der rothen Blutkorperchen." ArchiY filr 

 Mikrosk. Anatomie, vol. XIV (1877), pp. 73-93. 



(2) " Discovery of a new anatomical feature In human blood-corpuBcles." Chicago Medi- 

 cal Journal, May 15, 1868, and April 16, 1869. 



(3) " Contraction of Blood-corpuscles through the action of Cold." New York Medioal 

 Journal, March, 1877, p. 244. 



(4) " On the nucleus of red blood-corpuscles. " Arbeiten der St. Petersb. Gesellsch. d. 

 Naturf., vol. VII (1876), p. 129. (In the Kussian language.) 



(6) " Bemerkungen iiber die Kerne der rothen Blutkorperchen," Archiv. fur Mikrosk , 

 Anatomie. XIII, 2 (1876), p. 392. 



(6) "Structure of blood-corpuBcles." American Journal of Microscopy and Popular 

 Science, New York, June, 1878, p. 140. 



(7) Vorlesungen iiber allgemeine und experimentelle Pathologie, II Abtheilung, Wiea, 

 1878, p. 438. 



