The Structure of Colored Blood- Corpuscles. 297 



On the other hand, Schmidt and Schioeigger-Seidel, who 

 repeated B ditcher' 1 s early methods, using especially chloroform 

 as he had done, failed in finding nuclei, and suspected optical 

 illusion 1 . Klebs contradicted Bdttcher' 1 s statements as to the 

 presence of nuclei in normal mammalian red blood-corpuscles ; 

 but described the occurrence of nucleated red corpuscles in 

 blood taken from the corpse of a child who had suffered from 

 leucaemia, agreeing in so far with a like observation of 

 Bdttcher 2 . Brunn said 3 that lie had convinced himself that the 

 appearances produced by both of Bdttcher f s later methods are 

 artificial and optical effects, due to action of the re-agents on 

 the substance of the corpuscles. And, similarly, Eberharit 

 has come to the conclusion that the remains after the action 

 of different decolorizing reagents, are not nuclei, but stromata 

 deprived of coloring matter ; and that a formation, unmistak- 

 ably a nucleus, has not yet been demonstrated in adult human 

 and mammalian red blood-corpuscles." 4 



Among other questions as to the red blood corpuscle stated 

 by JBeale, 5 he asks : " Is it a living corpuscle that distributes 

 vitality to all parts of the organism, or is it simply a chemical 

 compound which readily absorbs oxygen and carbonic acid 

 gases and certain fluids? Is it composed of formative living 

 matter, or does it consist ot matter that is inanimate ? Does 

 it absorb nutrient matter, grow, divide, and thus give rise to 

 other bodies like itself, or dues it consist of passive material 

 destitute of these wonderful powers and about to be dissolved 

 into substances of simple composition and more nearly related 

 to inorganic matter ? " 



(1) ' Einige Bemerkungen iiber die rothen Blutkbrperchen." Berieht der Konigl. 

 Sachsischen Mesellschaft der Wissenschaften, 1867. p. 190. 



(2) •■ Ueber die Kerne und Scheinkerne der rothen Blutkorperchen der Siiugethiere." 

 Virchow's Archiv vol. 38 (1867), p. 200. 



(3) '• Ueber die den rothen blnt^orpercben der Siiugethiere zugeschiiebenen Kerne." 

 Archiv far Mikro3kopische Anatomie, vol. XIV. Heft 3 (1877), pp. 333-342. 



(4i TJeber die Kerne der rothen Blutkorperchen der Siiugethiere und des Menschen. 

 Inaugural-Dissertation der medizinisehen Faliultat zu Kduigsberg. April, 1877, p 30. 

 (5) Observations upon the Nature of the Ked Hlood-corpuscle ; I. c. p. 32. 



