36 Th. Lewis, 



tlie contents of many broken clown phagocytes liave apparantly run 

 together to form large spherical aggregations, often many times the 

 size of a phagocyte. These are presumably free, though in the case 

 of many of the smaller masses, a thin cell wall may be observed sur- 

 rounding a globular mass of pigment, and occasionally a nucleus is 

 to be seen. It is extremely likely in view of these facts, that after 

 red cells have been completely converted into pigment, either into 

 pigment masses of the same size, or into a number of minute masses 

 or granules of smaller size, that these masses tend to run together, 

 owing to increased pressure in the cell, and form larger masses. When 

 a phagocj'^te has reached this stage and is overloaded with pigment, 

 it is no longer serviceable in the sinus and wanders away to the ade- 

 noid tissue. Probably the adenoid tissue is reached through such 

 capillaries as are illustrated by flg. 5 c.a, in which phagocytes over- 

 laden with pigment are often found. Eeaching the adenoid tissue the 

 pigment is liberated, simultaneous with the death of the phagocyte, 

 which could not possibly be restored to its original form. The pigment 

 thus freed runs together into the large masses already desciibed, and 

 leaves the glands by the small veins communicating with the capillaries 

 just mentioned. 



Schumacher described in his first paper certain rod shaped enclo- 

 sures within the phagocytes, in his last contribution he stated that 

 he had not observed them with such frequency after the publication 

 of his first article; I have onlj^ very occasionally observed such appea- 

 rances. The same observer described leucocytes within the giant cells, 

 though he did not lay much stress on the observation. In this I am 

 able entirely to confirm him, and had indeed observed them before 

 seeing his paper (pi. I. fig. 11 j). They occur with considerable fre- 

 quency in some glands, particularly in hœmal lymphatic glands, and 

 it is often possible to make out stages in their disintegration (pi. I. 

 fig. 11 k). When first seen they give the phagocyte the appearance 

 of possessing two nuclei, but on closer inspection a difference in 

 staining, reaction between the two nuclei is noticeable, the smaller 

 nucleus closely resembling a cell such as is found in the lymphoid 

 tissue. It is probable that this form of destruction of leucocytes occurs 



