94 Swale Vincent and F. D. Thompson. 



conditions are newly formed by budding from the ducts, and Dale, 

 that much of the tissue escaping destruction assumes a form resembling 

 the islets. 



Lépine^) has shown that injection of oil into the duct of Wirsung, 

 or even simple ligature is followed by an increase in the glycolytic 

 powder of the blood. But he does not beliei^e^) that this blood change 

 is due to any action upon the islets of Langerhans. Lombroso'^) recently 

 reports that in dogs and pigeons complete occlusion of the ducts 

 produces no marked effect upon the pancreatic tissue. He admits 

 that in addition to the external secretion the pancreas has some other 

 function which persists even when the external secretion is abolished. 

 But he seems inclined to attribute this not specially to islets of Langer- 

 hans but to the general parenchyma of the gland. 



Schäfer'') was the first to suggest that the islets of Langerhans 

 are the parts of the pancreas concerned with carbohydrate metabolism. 

 A number of more recent observers (Opie^), Ssobolew*^}, Herzog'), 

 Weichselbaum*') and Stangl^) and Gentes®) have found in cases of dia- 

 betes mellitus the islets aiïected by a hyaline degeneration, atrophy, 

 or inflammatory changes, but Kasahara^^), Wright and Joslin ^^), V. Hanse- 

 mann^'-), Dieckhoff^-^), M. B. Schmidt ^^) and G-utmann^^) have been unable 

 to confirm these results. Notwithstanding the conflicting nature of 

 the experimental evidence on this point, a large number of patho- 



') Revue de Med. p. 486, 1892; p. 879, 1894; C. R. See. Biol. p. 1444. 

 21. Nov. 1903. 



2) Journ. de Physiol, et de la Path. Gén. p. 2. 1905. 



3) Journ. de Physiol, et de la Path. Gén. p. 3. 1905. 



^) Text-book of Physiology. Vol. 1. p. 930. Edin. et London 1898. „On 

 Internal Secretions," Brit. Med. Journ., London, August 1895. 



^) Loc. cit. 



«) Loc. cit. 



') Virch. Arch. Bd. 168. p. 83. 1902. 



•*) Wien. klin. Woch. Bd. 14. S. 968; Bd. 15. S. 969. 



«) C. R. Soc. de Biol. Vol. 55. p. 334. 1903. 

 '0) Virch. Arch. Bd. 143. S. 111. 1890. 



") Journ. of Med. Research Vol. (i. p. 3(iO. IJoston 1901 (July-Pec). 

 '2) Verh. d. Path. GcselLsch. Vol. 4. p. 187. 1901. 



'») Festschr. gewidiii. Th. Tiiierfcldc.r /,. 70. Gcluiilsiag. S. 95. Leipzig 1894. 

 ") Miiiich. Med. Wocli. \U\. 49. S. 51. li)02. 

 '^■j Viirh. Anil. lid. 172. S. 493. 1903. 



