208 Chalmers Watson, The influence of a meat diet on the kidneys. 



Muir's stain reveals a striking- alteration in the secretory granules of 

 tlie renal epithelium. 



VI. There is a noteworthy absence of cirrhotic change in the 

 flesh-feel animals, both in the first and second generations. 



VII. The observations on nitrogen metabolism show that the 

 flesh diet throws a special strain on the functional activity of the 

 kidneys, so far as regards nitrogen excretion. 



The expenses of this investigation have been defrayed by 

 grants from the Moray Fund of the University, and from the Car- 

 negie Trust. 



Description of Plate. 



Plate VI. 



B'ig. 1. Kidney of rat fed on a bread and milk diet. Muir's stain. Magnified 

 400 diameters. Note the size and distribution of the secretory granules 

 in the epithelium of the convoluted tubules. The granules are of uniform 

 size and limited to the deeper part of the cell. Cf. Fig. 2. 



Fig. 2. Kidney of rat fed on an ox-flesh diet. Muir's stain. Magnified 400 dia- 

 meters. The granules are not confined to the deeper part of the secreting 

 cells as in the bread and milk fed animal (Fig. 1), but are irregularly distri- 

 buted throughout the cell and are also present in the lumen. The granules 

 are considerably larger than in the control subject. 



