302 E- T. Bell, 



Ballowitz [1892] studied the muscle fibers of Cephalopoda. He 

 states that the interstitial granules are neither fat nor glycogen, but 

 probably consist of protaplasm different from that of the rest of the 

 fiber. 



Schaf fer' s paper [1893] is an extensive description of the dark and 

 light fibers in the various muscles of vertebrates. The granules are not 

 regarded as fat droplets except in those cases where they may be 

 blackened with osmic acid. He states that differences in the opacity 

 of the fibers are not all due to differences in the content of interstitial 

 granules. Contracted portions of a fiber appear as light fibers in fresh 

 preparations, and as dark fibers in fixed and stained preparations. 



Altmann [1894] figures and describes rows of fuchsinophile gran- 

 ules between the fibrils in the muscle fibers of the frog, the tadpole, 

 and the wing muscle of Dytiscus. 



Galeotti [1895] describes fuchsinophile granules in the muscles of 

 amphibians (Spelerpes). Fuchsinophile granules are present in the 

 muscle fibers of the young larvae of Triton. He believes that the gran- 

 ules are formed from the yolk droplets and that they are metabolic 

 products of the fiber. 



Whether the fuchsinophile granules described by Altmann and others 

 are identical with the interstitial granules of other observers will be 

 discussed later. 



Walhaum [1899] finds fat droplets in varying quantity in the muscle 

 fibers of children in about two-thirds of the cases examined. The fat 

 content of the fibers bears no relation to the nutritive condition. Sec- 

 tions of formalin-fixed tissue were stained in sudan III to demonstrate 

 the fat. He notes that decidedly fewer droplets are stained than can 

 be seen in the fresh material. He evidently failed to stain a consider- 

 able proportion of the interstitial granules. 



Bicker and Ellenbeck [1899] apparently found no fat at all in the 

 muscle fibers of normal rabbits. Altmann's fixative was used to demon- 

 strate the fats. Evidently their results apply only to osmic-staining 

 granules. 



Albrecht [1902 — 1903] finds small fat-like bodies (liposomes) in all 

 cytoplasm. In this category belong the interstitial granules of muscle 



