166 



G. G. Heslop.- 



sembling spirilla and spirochetes, which originated from single 

 granules. 



Following closely on the work of Borrel, Dujardin-Beaumetz,. 

 Jeantet and Jouan, and on that of Bordet, Martinovski (8), in 

 1911, published an account of his observations of the organisms- 

 in cultures and in sections of diseased tissue. He also remarked 

 upon the polymorphism of the organism, and after having 

 described various forms, some of them similar to some of those 

 observed by Borrel, he concludes that " the study of the pleuro- 

 pneumonia microbe in the tissues of infected animals, and in the- 

 cultures, allows us to classify the microbe of Nocard and Roux 

 in the group of cocco-bacilli, so that the name " Coccobacillus> 

 mycoides peri-pneumonic " would suit it well, as it indicates all 

 the properties of this singular organism. " 4 



K. F. Meyer (1909) (9) described in detail the pathological 

 changes which occur in the lungs and other tissues in naturally 

 infected cases of contagious pleuro-pneumonia, and also the 

 changes which occur in tissues following a subcutaneous injec- 

 tion of virus in the dewlap or in the tail. He states :— " It is 

 interesting to demonstrate that whichever tissue may have been 

 the seat of injection of pleuro-pneumonia virus, it always shows 

 exactly the same changes as have been described as being found 

 in the interstices of the lungs under natural infection." 5 



It is of passing interest to note that Meyer, in referring to 

 the complications such as necrosis of the tail, peritonitis, etc., 

 which sometimes follow the inoculation of virus, remarks: — 

 " It has been stated that contamination of the vaccine is the cause 

 •of complications. I quite disagree with such a notion, for work- 

 ing with absolutely pure cultures, and taking all aseptic precau- 

 tions, we yet cannot avoid having losses. Individual disposition^ 

 or weakening of the constitution form the cause of the mis- 

 fortune." 6 



Boynton (1912) (5) has shown, as a result of a close study 

 of the muscular changes brought about by intermuscular injec- 

 tion of infected material into otherwise healthy bovines, that the 

 lesions occurring in the muscles following such injections are his- 

 tologically comparable with the lesions occurring in the lungs in- 

 cases of the disease naturally acquired. 



P. 917. 

 F. 153. 

 P. 153. 



