Fatigue of Excitation and Fatigue of Depression etc. 37 



of these, the largest and smallest, weighing- 980 and 560 grams 

 respectively, were killed without disturbance as controls (Experiment 

 Normals 13 and 14). Of the others, two (Experiments 23 and 24 in 

 the continuation of the Muscular Exertion series, 1909 c) were trans- 

 fused with the blood of fatigue, one (Experiment M.-E. 25) was trans- 

 fused from the presumably normal blood of the mother as a control 

 of the effect of the operative excitation and one (Experiment M.-E. 26) 

 was treated intravenously with lactic acid. With these common points 

 set forth, the details of each experiment may be given in brief. 



Experiment M.-E. 22. The donor. In the treadmill three hours 

 and nine minutes, with work and rest alternating. Early exhaustion. 

 Total working time one hour. 



Experiment M.-E. 23. First recipient. Anastomosis of carotid 

 artery of Experiment 22 to jugular vein of Experiment 23 by means 

 of Queirolo's cannula as adapted by Crii e (1909) and Hitchings. Bled 

 from the femoral artery to a failing pulse, transfused, which again 

 was followed by a double repetition of both these consecutive 

 procedures. Total time from beginning of anesthetic to removal 

 from table was fifty-three minutes. Killed after six hours. 



Experiment M.-E. 24. Second recipient. Single repetition of 

 bleeding and transfusion. Total time of operation, thirty minutes. 

 Killed after three hours. 



Inside of one half hour both puppies were awake, walked around 

 and no decided change in their behavior was noticeable. 



Experiment M.-E. 25. Control transfusion from normal mother. 

 Previous experiments imitated. A final transfusion in excess caused 

 respiratory and cardiac embarrassment which necessitated a final 

 bleeding. Total time of operation fifty-seven minutes. This puppy 

 received the most extensive operative handling of the three. Killed 

 after six hours. 



Since very young puppies were found later to offer difficulties in 

 comparison for reasons to be explained, the transfusion experiment 

 was repeated on a known elderly dog. 



Experiment M.-E. 32. The donor. Weight 8 kg. In the tread- 

 mill two hours, total work sixty-eight minutes. 



