54 David H. Dolley, 



point is to the cytolcgist clearly defined in the single statement: 

 "La chromolyse peut être très bien expliquée sans qu'il soit néces- 

 saire d'admettre la consommation d'une substance." That idea may 

 fall of itself. 



Lee (1906), after quoting- Joteyko's conclusion in the wcrds "the 

 reflex mechanism of the cord is practically indefatigable", says: "If 

 this be true, why may not the same be said of the brain centres?" 

 And again: "Moreover, the same results (namely, in favor of earlier 

 fatigue of the muscular than of the nervous mechanism) make it 

 probable that the brain and spinal cord are, like the nerve "fibre, 

 resistant, and they throw a certain measure of dcubt en all supposed 

 proofs of central fatigue." While he says: "We cannot deny fatigue 

 to psychic centres," yet for him it is largely a matter of sensation, 

 peripheral in origin, and this and the waste products of activity 

 therewith associated are apparently adequate to explain not only the 

 subjective feeling of fatigue but essentially the fatigue itself. For 

 fairness, however, in another place he says: "Concerning a pcssible 

 relation of the loss of other substances (namely, other than carbo- 

 hydrates) to fatigue, our present knowledge permits us to say nothing." 

 Again, in a later paper (1909), in speaking of what he terms "pseudo- 

 fatigue", after direct stimulation of the tracts of the cord, he says: 

 "One cannot help thinking that the fatigue of such an experiment, 

 which follows a few contractions, is not genuine or complete fatigue 

 at all, comparable tu that resulting from the action of the toxic 

 fatigue substances or the loss of substance essential to activity." 

 This is quoted for the final clause and the opinion of the resistance 

 to fatigue more evidently relates to a relative one. 



Tissié and Blumenthal (1908) in their study of the effects of 

 strenuous mountain climbing ascribe them solely to auto-intoxication, 

 without even considering the possibility that certain of the nervous 

 phenomena may be sui generis. 



Burridge (1910) in his study of the chemical factors of fatigue 

 says in introduction: „Thus there is return to the older view that 

 fatigue is peripheral and that normal fatigue is rather a condition in 

 which the stimuli sent out from the central nervous system, in all 



