The ri'hiliipiis of iMii(i(|i(iiiilri;i ;inil oIIht cytoplasmic constituents etc. 495 



therefore, tliiil llic r.iiiiiciincl/ ol KKpsdi icsults fi-om the lilackeiiiiiìr 

 of tlie contents oJ a system ol clear caiiuls hy osiuic acid, similar in 

 all respects to those desciihed by Nelis, Holinpfren, and otliers. Plate X\'I 

 and the first I'uw of fis>'nres in plate XVII are designed to show the 

 morphological siniilaiity of this canalieiilar system as demonstrated 

 by the methods of Nells, Holnigien, l\op>(li. Bensley, and l\ini;sbniy. 

 In the first vertical column of figures the canals are shown distrib- 

 uted equally in the cytoplasm, in the second they are represented 

 clumped together in an excentric fashion, and in the third a typical, 

 continuous, circumnuclear, network is seen. 



The conclusion to be drawn is that the spiremes of Xelis, the 

 Saftkanälchen of Holmgren, the Binnennetz of Kopsch, and the canali- 

 cular system demonstrable by the methods of Bensley and Kingsbury 

 are one and the same thing, and are quite independent, morpholog- 

 ically, of other cytoplasmic constituents. We have to deal, therefore, 

 with the following synonyms for this canalicular system in nerve 

 cells: spiremes, Saftkanälchen, Binnennetz, internal net, intracellular 

 canals, etc. 



Cajal (1908) has studied the relation of the internal reticular 

 apparatus of Golgi to the Saftkanälchen oi- juice canals of Holmgren, 

 has come to the conclusion that they are identical, and consequently 

 refers to them as the "conduits de Golgi-Holmgren"'. This is the 

 consensus of opinion of most investigators. My own preparations, 

 made by Golgi's latest method, are not sufficiently- clear to warrant 

 any conclusions; but the morphological similarity of the excentric 

 and circumnuclear types Of canalicular network, particularly those 

 shown in the Kopsch preparations, and the internal reticular apipar- 

 atus of Golgi is very remarkable. Compare figures 19 to 42 with 

 Golgi, 1899, figures 1 to 8. Moreover. Golgi has recorded (1899, 

 p. 279) the breaking up of the reticular apparatus into island-like 

 fragments in the spinal ganglion cells of a dog about two years old. 

 This seems to be similar to the condition of the clear canals shown 

 in fig. 40. So close a morphological correspondence in the form of 

 the reticular apparatus of Golgi and the canalicular system is espec- 

 iallv sig-nificant in view of the extreme variabilitv of these structures. 



