52 The Philippine Journal of Science 



Six dogs were used as controls; two received hypodermic in- 

 jection of 6.7 milligrams of uranium nitrate per kilogram of. 

 body weight for two days in succession, and the remaining four 

 received daily injections of sterile saline solution. The saline 

 controls were autopsied after they had received the same number 

 of injections as the emetinized animals. Saline solution did 

 not produce hemorrhages at the places of injection nor abnormal 

 changes in the urine and the kidneys, except the appearance of 

 the short hyaline casts that were noted in the urine of three 

 dogs already referred to. Their appearance cannot be ascribed 

 to the injection of saline solution, because they were observed 

 to appear periodically in the urine of these dogs even before the 

 injections. Uranium nitrate caused the appearance of albumin, 

 desquamated renal cells, granular casts, and finally anuria. 

 When autopsied seven days after the first injection of uranium 

 nitrate, one dog showed hemorrhage at the point of injection, 

 anasarca, and acute tubular nephritis, while the other showed 

 acute diffuse nephritis involving especially the tubules. 



CONCLUSIONS 



Our results show that emetine hydrochloride gave rise to con- 

 gestion and slight parenchymatous degeneration of the kidneys. 

 While in one dog the drug produced hemorrhages at the sites 

 of injection and between the layers of the renal capsule, and at 

 the site of injection in another dog, in no case did its irritant 

 action extend to the parenchyma of the kidneys, although we 

 administered it in a quantity that, when injected daily, even- 

 tually caused the death of the animals. 



We wish to thank Professor B. C. Crowell, of the department 

 of pathology and bacteriology, University of the Philippines, for 

 examining the sections of the kidneys. 



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