70 The Philippine Journal of Science ms 



the effect of the treatment on the regeneration of the bone at 

 the sites of the bone lesions was studied by radiographs taken 

 at monthly intervals as nearly as was practicable. In every case 

 the clinical and subjective symptoms disappeared long before the 

 radiographs showed the bone lesions to have disappeared. 

 The histories of the most important cases are as follows : 



CASE 1 



B. U., Filipino, 8 years old. The primary lesion was on the 

 right leg, while the patient was still a nursing baby. The sec- 

 ondary lesions appeared soon afterward and were most mani- 

 fest on the hands and about the mouth. The secondary lesions 

 gradually disappeared without treatment, but the mother yaw 

 remained for over a year. Five years later the proximal pha- 

 lanx of the index finger of the right hand became swollen and 

 enlarged. Soon the adjacent fingers became similarly involved, 

 but the patient stated that the fingers were not painful. On 

 February 10, 1917, the X-ray pictures showed a total of nineteen 

 bone lesions including those on the articular surfaces. The Cas- 

 tellani treatment was given in one-half the adult dose, but the 

 patient soon complained of gastric disturbance and headache. 

 The amount was then reduced to one-fourth the adult dose. 

 After five months the bone lesions showed definite improvement, 

 and considerable regeneration of the bones had taken place. 



CASE 2 



M. S., Filipina, 10 years old. The primary lesion was on the 

 left leg in 1915. The secondary eruption, which appeared six 

 weeks later, gradually disappeared after the third month with- 

 out treatment. In August, 1916, she complained of pain in the 

 left leg, which condition persisted until she was seen in Feb- 

 ruary, 1917. The X-ray pictures at this time showed one lesion 

 in the lower part of the tibia and four in the os calcis. Further 

 observation of this case was not possible. 



CASE 3 



P. G., Filipina, 15 years old. The primary lesion appeared 

 on the left leg in October, 1911. This lesion improved without 

 treatment, but did not completely heal. The secondary eruption 

 appeared three weeks later and was most marked upon the feet. 

 Other lesions were scattered about the face, anus, and vulva. 

 After one and one-half years the eruption had disappeared ex- 

 cept from the lower extremities. It was elicited that severe 

 rheumatoid pains involving all the joints developed about six 

 months after the appearance of the primary lesion and persisted 



