72 The Philippine Journal of Science wis 



arm was flexed at the elbow and made useless by a contracture 

 on the anterior surface of the joint. This contracture had per- 

 sisted for the past year. At this time the Castellani treatment 

 was started in one-half the adult dose, and by the end of the 

 second week the contracture had disappeared, but the painful 

 bone lesions persisted for some time. Rbntgenograms after full 

 five months' treatment showed a marked improvement of the 

 lesions, but regeneration was not complete. While taking the 

 treatment, the patient vomited on several occasions, showed 

 marked depression on the fifth day, becames salivated, and had 

 severe catarrhal symptoms. 



CASE 5 



A. G., Filipino, 26 years old. The primary lesion appeared 

 in August, 1914. This lesion persisted about one month. One 

 month later the secondary eruption appeared about the axilla, 

 elbows, mouth, anus, and prepuce, and these lesions disappeared 

 without treatment, but soon afterward contractures of the ex- 

 tremities and severe rheumatoid pains in the feet developed. 

 These conditions existed for about two years, and at the time 

 I first saw him, he was able to get around and do light work. 

 The X-ray pictures showed bone lesions in the left os calcis, on 

 the articular surface of the upper extremity of the left tibia, 

 and on the phalanges of the hands. The patient was started on 

 the Castellani treatment February 10, 1917, and by February 25 

 marked improvement was evident. To hasten the recovery of 

 the case, 0.2 gram of salvarsan was given intravenously, but 

 the case did not return subsequently and could not be followed. 



CASE 6 



A. S., Filipino, 60 years old. The primary lesion appeared 

 on the right leg on June 5, 1915. Two months later he de- 

 veloped the secondary eruption and a varicose condition of the 

 veins of the middle finger of the right hand. The finger became 

 twice its normal size and was spindle-shaped, boggy, and worm- 

 like to the touch, but was not painful. (It is questionable if 

 this condition had any relation to the yaws.) He complained 

 of pain in the tibia and femur, which had existed for one year 

 at the time he was first seen on February 10, 1917. The ront- 

 genograms showed a total of ten lesions. Those of the phalanges 

 of the hands showed a marked narrowing of the cortex of the 

 bones, while the one on the upper end of the tibia was on the 

 surface of the bone and was excavated in character. He was 

 given the Castellani treatment, which he took regularly, and 



