98 The Philippine Journal of Science ms 



grains of cacodylate of soda. The temperature decreased 

 on May 20, but the animal presented marked symptoms of 

 photophobia. 



May 21-23, diarrhoea, not eating. 



This animal died May 23, presenting marked lesions of rinder- 

 pest upon autopsy. 



EXPERIMENT 5 



Batanes bull 3135. — This animal had been injected with viru- 

 lent rinderpest blood. 



May 23, 1911, eighteen hours after the first rise in temperature, 

 this animal was injected intravenously in the femoral vein with 

 3 grains of cacodylate of soda. 



May 24, this animal presented symptoms of photophobia. 



May 25, eating little. 



May 26-28, diarrhoea, not eating. 



May 28, died of rinderpest, presenting marked lesions. 



From the results of experiments 3, 4, and 5, it will be seen 

 that cacodylate of soda as it was used in these cases had no ill 

 effect upon the virus of rinderpest and, if anything, aggravated 

 the disease, causing a much more pronounced photophobia than 

 is normally present in rinderpest and also more pronounced 

 intestinal lesions than are usually noticed. From these results 

 it appears that arsenic compounds are contraindicated in 

 rinderpest. 



ATOXYL 



Atoxyl was tried because it has such a pronounced action 

 in clearing the blood stream of trypanosomes in cases of surra 

 infection, and there was a possibility that it might have a similar 

 action upon the virus of rinderpest. 



EXPERIMENT 6 



Batanes bull 3119. — This animal had been injected with 30 

 cubic centimeters of virulent rinderpest blood serum 2 on July 

 8, 1911. 



July 11, it presented a rise in temperature, registering, in the 

 afternoon, 40.2° C. 



July 12, it developed a diarrhoea. 



July 14, which was the third day after the initial rise in tem- 

 perature, this animal was injected subcutaneously with 5 grams 

 of atoxyl dissolved in 60 cubic centimeters of sterile distilled 

 water. 



1 Virulent rinderpest blood was allowed to stand in the ice box for twenty- 

 four hours, then the serum was drawn off and injected. 



