xiii, b, 2 Boynton: Treatment of Rinderpest 99 



The animal's temperature dropped to slightly high normal 

 shortly after the injection, registering 39.4° C, but it presented 

 marked symptoms of photophobia. 



July 16, this animal died, presenting marked lesions of rinder- 

 pest upon autopsy. 



The atoxyl gave symptoms similar to those of the cacodylate of 

 soda and appeared to stimulate the virus instead of retarding 

 its action. 



QUININE SULPHATE 



Quinine sulphate was used with the idea that it might have an 

 action upon the virus of rinderpest similar to that which it 

 has upon malaria. Its antipyretic action was also taken into 

 consideration. 



EXPERIMENT 7 



Batanes bull US15. — This animal was injected on November 

 24, 1911, with 25 cubic centimeters of rinderpest blood that had 

 been kept in a clotted form in a large test tube for ninety-six 

 hours in the incubator at 37° C. The clotted blood was taken 

 from the test tube and macerated in a sterile mortar with a 5 

 per cent potassium citrate solution, and the liquid material thus 

 obtained was injected. 



November 30, in the forenoon, this animal presented its first 

 rise in temperature, registering 39.6° C. 



December 1-2, diarrhoea, eating little. 



December 3-4, diarrhoea, not eating. 



December 4, this animal was given quinine sulphate in cap- 

 sules per orum in the following doses: 



Grams. 



8.30 a. m. 5 



11.30 a. m. 5 



2.30 p. m. 5 



5.30 p. m. 5 



This animal died during the night of December 4 and pre- 

 sented good lesions of rinderpest upon autopsy. 



From this experiment it will be noted that the animal received 

 20 grams of quinine sulphate per os with no effect upon the 

 disease, although it was in the last stages of the disease when 

 the treatment was undertaken. 



EXPERIMENT 8. QUININE SULPHATE AND ERGOT 



Fuga carabao 67. — This animal was injected on January 28, 

 1917, with 50 cubic centimeters of virulent rinderpest blood 

 from carabao 65. 



