xiii, b, 2 Boynton: Treatment of Rinderpest 109 



SERUM, NUCLEIN, AND ADRENALIN CHLORIDE 



Nuclein was used to try to develop a leukocytosis in the ani- 

 mals and thus increase their resistance, since one of the chief 

 symptoms in rinderpest is a leukopenia. 



Adrenalin chloride was used to tone up the blood-vessel walls, 

 since in rinderpest the virus or its product has a direct action 

 upon the capillary walls, causing them to lose their tone and 

 thus become markedly distended with blood, which leads to stasis, 

 diapedesis, and exudation, the exudates coagulating and causing 

 coagulation necrosis. 



The serum was injected to give the animal a supply of anti- 

 bodies and thus increase the resistance. 



EXPERIMENT 28 



Batanes bull 4-165. — This animal was inoculated on January 

 5, 1917, with 50 cubic centimeters of virulent rinderpest blood 

 from bull 4162. 



January 9, bull 4165 presented its first rise in temperature, 

 registering, in the forenoon, 39.2° C. 



January 10, in the forenoon, administered subcutaneously 200 

 cubic centimeters of antirinderpest serum and 15 cubic centi- 

 meters of nuclein solution ; in the afternoon, 10 cubic centimeters 

 of adrenalin chloride. 



January 11, in the forenoon, administered subcutaneously 15 

 cubic centimeters of nuclein solution and 10 cubic centimeters 

 of adrenalin chloride; in the afternoon, administered 15 cubic 

 centimeters of nuclein solution and 10 cubic centimeters of adre- 

 nalin chloride. 



January 12, in the forenoon, animal looked bright; slight 

 diarrhoea; temperature 38.5° C. ; administered subcutaneously 15 

 cubic centimeters of nuclein solution and 10 cubic centimeters 

 of adrenalin chloride; in the afternoon, not looking so well; 

 diarrhoea, not eating; administered 15 cubic centimeters of 

 nuclein solution and 10 cubic centimeters of adrenalin chloride; 

 temperature 38.8° C. 



January 13, animal very weak; temperature 36° C; adminis- 

 tered 10 cubic centimeters of tincture of nux vomica and 10 cubic 

 centimeters of 70 per cent alcohol. 



Animal died in the afternoon, presenting good lesions of 

 rinderpest. 



Although the administration of nuclein and adrenalin chloride 

 appeared to hold in check the more severe symptoms of rinder- 

 pest for some time, it has no effect upon the final termination 

 of the disease. 



