HO The Philippine Journal of Science 1913 



DARIN'S CHLORAZENE 



Dakin's chlorazene was used with the idea of either destroying 

 or attenuating the virus of rinderpest to such an extent that the 

 animal would be able to overcome the disease and recover. 



Chlorazene is an ideal antiseptic to use, since it has no cor- 

 rosive action. It neither precipitates nor coagulates proteins, 

 such as blood serum. It is practically nontoxic even when in- 

 jected hypodermically. It is extremely stable and is a powerful 

 disinfectant in very high dilutions. 



EXPERIMENT 29 



Batanes bull A322. — This animal contracted rinderpest by ex- 

 posure to sick animals. 



July 15, 1917, bull 4322 presented its first rise in temperature, 

 registering, in the forenoon, 38.9° C. 



July 17, administered intravenously 1,000 cubic centimeters 

 of sodium chloride solution in which 13.8 grains of chlorazene 

 had been dissolved; animal took injection without a struggle. 



July 18, administered intravenously 1,000 cubic centimeters of 

 sodium chloride solution in which 5 grams of chlorazene had been 

 dissolved; the animal began to eat immediately after injection. 



July 20, administered intravenously 1,000 cubic centimeters 

 of sodium chloride solution in which 5 grams of chlorazene had 

 been dissolved; withstood injection well. 



This animal did not develop any symptoms of rinderpest 

 except a rather high normal temperature, and it was thought 

 possible that a cure had been effected. It was left in immediate 

 contact with animals in various stages of the disease. 



July 29, bull 4322 again presented a high temperature, regis- 

 tering, in the forenoon, 39° C. ; in the afternoon, 40° C. 



August 1, as this animal continued to run a high temperature, 

 it was decided to administer chlorazene again. It received in- 

 travenously 1,000 cubic centimeters of sodium chloride solution 

 in which 4 grams of chlorazene had been dissolved. 



August 3, diarrhoea, not eating; administered intravenously 

 1,000 cubic centimeters of sodium chloride solution in which 4 

 grams of chlorazene had been dissolved. 



August 4, diarrhoea, not eating; very sick. 



August 5, died during the night of August 4, presenting good 

 lesions of rinderpest. 



There is a question as to whether bull 4322 was suffering 

 from rinderpest during the first administration of the drug. 

 If it was suffering from rinderpest, the chlorazene injections evi- 



