xiii, b, 2 Boynton: Treatment of Rinderpest 111 



August 18, bloody diarrhoea; not eating. 



August 19, bloody diarrhoea; not eating. 



August 20, animal found dead in the morning; good lesions 

 of rinderpest. 



From the results obtained in experiments 41 to 43, inclusive, 

 it will be noted that antirinderpest serum had no protective 

 effect upon the final outcome of the disease when injected in as 

 large a dosage as 1,000 cubic centimeters. 



Antirinderpest serum is very effective when used before the 

 symptoms of rinderpest make their appearance. 



It is also beneficial when administered in large quantities to 

 animals that have a high resistance or are infected with an 

 attenuated strain of virus. When handling animals that are 

 highly susceptible, such as are used in the laboratory in experi- 

 mental work, when such animals are infected with a highly 

 virulent strain of rinderpest, such as is used in the laboratory 

 in carrying on experiments, and when this type of animal pre- 

 sents the first symptoms of the disease, then the administration 

 of antirinderpest serum is of no benefit as a protective or 

 curative agent. 



CANABIS INDICA AND SERUM 



Canabis indica was used for its antispasmodic, analgesic, 

 and narcotic action and also to stimulate the appetite. It was 

 thought that possibly by the action of the drug and the support 

 it would receive from the antirinderpest serum there might be 

 a chance of the animal developing enough resistance to overcome 

 the disease. 



EXPERIMENT 44 



Batanes bull 4313. — This animal contracted rinderpest by ex- 

 posure to sick animals. 



July 31, 1917, bull 4313 presented its first rise in temperature, 

 registering, in the afternoon, 40.2° C. 



August 1, given subcutaneously 300 cubic centimeters of anti- 

 rinderpest serum and intravenously 5 cubic centimeters of fluid 

 extract of Canabis indica. 



August 2, administered intravenously 5 cubic centimeters of 

 fluid extract of Canabis indica. 



August 3, diarrhoea, not eating; administered intravenously 

 8 cubic centimeters of fluid extract of Canabis indica,. 



August 4, diarrhcaa, eating little; administered intravenously 

 10 cubic centimeters of fluid extract of Canabis indica. 



August 5, diarrhoea, eating little; administered intravenously 

 10 cubic centimeters of fluid extract of Canabis indica. 



