xni, b,2 Boynton: Treatment of Rinderpest H9 



August 8, animal found dead in the morning; good lesions 

 of rinderpest. 



From the results obtained in experiments 44 to 46, inclusive, 

 it will be noticed that the administration of fluid extract of Ca- 

 nabis indica and antirinderpest serum had no effect upon the 

 final outcome of the disease. The animals used in experiments 

 44 and 45 continued to eat for a much longer time than is usually 

 the case in a fatal attack of rinderpest, and in this respect the 

 Canabis indica helped them. They also did not develop ulcers 

 in their mouths until the day before death. 



MEDICINAL METHYLENE BLUE 

 EXPERIMENT 47 



Fuga bull U32U. — This animal contracted rinderpest by expo- 

 sure to sick animals. 



August 8, 1917, bull 4324 presented its first rise in temper- 

 ature, registering 39.9° C. 



August 9, administered intravenously 800 cubic centimeters 

 of sodium chloride solution in which 1 gram of medicinal methy- 

 lene blue (Merck) had been dissolved; in the afternoon diarrhoea 

 beginning. 



August 10, bloody diarrhoea; not eating; administered intra- 

 venously 500 cubic centimeters of sodium chloride solution in 

 which 0.5 gram of medicinal methylene blue had been dissolved. 



August 11, bloody diarrhoea; not eating; animal very sick; 

 administered intravenously 500 cubic centimeters of sodium 

 chloride solution in which 0.8 gram of medicinal methylene blue 

 had been dissolved. 



August 12, animal found dead in the morning; good lesions 

 of rinderpest. 



From the results obtained in experiments 2 and 47 it will be 

 noticed that medicinal methylene blue has apparently no detri- 

 mental effect upon the virus of rinderpest when administered 

 either subcutaneously or intravenously. 



MISCELLANEOUS EXPERIMENTS 



The data on the following experiments cannot be located, 

 but I have the results of these experiments in mind. 



1. During 1913 a small Batanes bull suffering from an attack 

 of rinderpest was injected intraperitoneally with quinine sul- 

 phate that had been dissolved in acidulated sodium chloride 

 solution. This animal recovered from the disease. Without 

 doubt the animal would have made a recovery without any 



