THE PHILIPPINE 



Journal of Science 



B. Tropical Medicine 



Vol. XIII JULY, 1918 No. 4 



STUDIES ON CRYPTOPLASMIC INFECTION. I, DEVELOPMENT 

 OF A CRYPTOCOCCUS IN CULTURES FROM AN UNCLA^"" 

 SIFIED CHRONIC PHILIPPINE ULCER * 



By H. W. Wade SFP 4 



(From the Biological Laboratory, Bureau of Science, Manila) 



FIVE PLATES 



GENERAL HYPOTHESIS 



In the pathology of fungous infections of the deeper tissues 

 there are sometimes noted features difficult to explain on the basis 

 of the recognized factors of infection. Having been interested 

 by certain such observations on the American "blastomycosis," 

 so-called, I was led to undertake a study of mycotic lesions as 

 they occur in the Philippine Islands. From the outset there 

 were encountered difficulties and peculiarities, and a number 

 of observations have been made that, for their explanation, have 

 led to the formulation of a tentative hypothesis that departs 

 radically from orthodox views. Though it is impossible as yet 

 fully to define these observations, it seems desirable to outline 

 their chief features in order to indicate the line of investigation 

 to which they have led. 



Essentially it appears as if the differentiated, demonstrable 

 parasitic element in a mycotic lesion may give rise to a deriva- 

 tive substance, morphologically not differentiated and perhaps 

 even quite amorphous, that, unlike the known "toxins," soluble 



1 This article, though preceded by three others having to do with certain 

 infectious fungi and the lesions caused by them [Journ. Inf. Dis. (1916), 

 18, 618; Arch. Int. Med. (1916), 18, 103; and This Journal, Sec. B (1916), 

 11, 267], is the first paper of a contemplated series based on a group of 

 more or less related observations and experimental studies, by the sum 

 total of which it is hoped that the general hypothesis here outlined may 

 be established. 



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