192 The Philippine Journal of Science ms 



oxide. The sediment, however, disappears when each dose is 

 diluted with four times the amount of water or when 8 cubic 

 centimeters of glycerin are added to the formula. 



Castellani tried this formula in eleven cases given in the doses 

 mentioned for from ten to fifteen days, followed by from five to 

 ten days of rest, then another course for another five or ten or fif- 

 teen days. His results were very satisfactory in recent and fairly 

 recent cases, in which the disease had started three to twelve 

 months previously. In chronic cases the results were much less 

 satisfactory. Very mild symptoms of iodism were observed in 

 three cases, but were not sufficiently severe to necessitate stop- 

 ping the treatment or decreasing the doses. No symptoms point- 

 ing to any depressing action on the heart were noted. 



Spaar(5) obtained excellent results with this treatment in 

 three cases, the patients recovering in two or three weeks. 



We have used this treatment in more than 43 cases, including 

 7 in the Philippine General Hospital, 14 in Paranaque, and 22 

 in Las Pinas. The cases in the Philippine General Hospital 

 were all discharged completely cured. 



With the exception of four, all our cases presented, more or 

 less moderately, one or several of the following symptoms during 

 the treatment: General malaise, weakness, slight fever, nausea, 

 vomiting, gastralgia, diarrhoea, pharyngitis, ptyalism, intense 

 coryza, lachrymation, congestion of the conjunctiva, cephalalgia, 

 and insomnia. One case also presented slight induration or 

 nodules of the skin of the face and ears, and another presented 

 erythematous patches in various parts of the body. However, 

 we did not observe in those cases who were under our immediate 

 supervision furunculosis, acne, purpura, nor oedema of the eyelids, 

 face, and larynx. The method of administration followed by 

 us brings about gradual saturation of the body. We gave on 

 the first day one-third dose three times ; on the second day, one 

 dose twice; and on the subsequent days, one dose three times 

 daily. We adopted this dosage in order to ascertain the suscep- 

 tibility and gradually to establish tolerance in the patient. The 

 number of doses necessary to effect a cure varied from 15 to 

 80, and the time elapsing from the commencement of the treat- 

 ment till complete recovery was from five to twenty-seven days. 



Of the 14 cases of Paranaque, 10 showed complete recovery, 

 while the remaining 4 showed only improvement of the symptoms. 

 Seven of the Las Pinas cases discontinued the treatment early, 

 3 showed improvement of symptoms, 3 proved refractory, and 

 9 recovered completely. To summarize: Of the 36 cases that 

 continued the treatment, 24 completely recovered, 7 showed im- 



