194 The Philippine Journal of Science ibis 



swelling of all the joints. The bones of the fingers were markedly enlarged. 

 He took 24 doses, and after nine days in the hospital the symptoms dis- 

 appeared and the lesions healed. 



Case VI. — S. P., 17 years old, male, had yaws for a month. There were 

 papules covered with a yellowish crust in the right nostril, and there were 

 also scars. The patient entered the hospital on account of pain in the bones 

 and swelling in the joints. He said he had had a similar attack one year 

 ago. He took 14 doses in six days. The treatment caused amelioration 

 of the pain and of the lesions. 



Case VII. — A. M., male, 40 years old, contracted yaws four years ago. 

 He came for treatment of an old ulcer on the right forearm. It measured 

 about 4 centimeters in diameter. The edges were irregular and elevated, 

 and the base was covered with yellowish purulent material. The patient 

 stayed in the hospital twenty-seven days, during which time he took 80 doses. 

 The ulcer had completely healed when he was discharged from the hospital. 



Case VIII. — L. S., male, 31 years old, had yaws for one year and four 

 months. The lesions were granulomatous nodules of from 1 to 1.5 centi- 

 meters in diameter. They were found on the neck and chest. The face 

 showed numerous pigmented scars. The patient was given 10 drops of a 

 saturated solution of potassium iodide three times daily for nine months. 

 The iodide produced only insignificant improvement of the eruptions on the 

 face. Castellani's mixture was then given, and in five days the lesions 

 completely healed. 



Case IX. — F. C, female, 40 years old. The patient said she had had an 

 eruption eight years ago. She came for treatment of an ulcer on the right 

 external malleolus. The ulcer was of five months' duration. It was about 

 4 centimeters in diameter and was covered with fetid whitish material; the 

 border was elevated. The ulcer completely healed after the patient had 

 taken 39 doses in a period of fifteen days. 



Case X. — F. de G., 40 years old, male, had yaws for one year. The lesion 

 appeared as an abrasion of the skin of the forehead. It later developed 

 into an ulcer. There were four ulcers on the forehead, from 5 to 10 

 centimeters in diameter, at the time of treatment. The edges were elevated 

 and granular. Castellani's treatment caused complete cicatrization of the 

 ulcers. 



Case XI. — C. S., female, 16 years old, was ill for four months. At first 

 she had a febrile pain in the joint and itching of the skin over the left knee. 

 The skin then became covered with a yellow crust, which she thought was 

 scabies. Later small papules appeared around the lesion on the knee. 

 These spread in two weeks all over the body and assumed the characteristic 

 appearance of the manifestation of yaws. The patient believed she had 

 contracted the disease from a visitor who had the same disease. She took 

 47 doses in eighteen days, and the lesions completely disappeared. 



Case XII. — J. F., 34 years old, was the mother of case XI. She had 

 yaws for three months. The lesions consisted of granulomatous papules 

 on the face and hands and of scaly eruptions on the forearm. The latter 

 were arranged in the form of islands 3 to 4 centimeters in diameter. She 

 was admitted with case XI. After 41 doses, given in sixteen days, she 

 recovered completely. 



Case XIII. — J. T., 27 years old, married, female, had yaws for three 

 months. The mother yaw was found on the left middle finger. Seven days 

 later granulomatous papules appeared on the face and other parts of the 



