272 The Philippine Journal of Science i9is 



beneath the small scar. About July 1 observation was discon- 

 tinued, the animal being apparently negative. 



She did not gain weight, however, and the young one appeared 

 to be undernourished. After three months more both animals 

 were very thin, though in neither was any definite evidence of 

 disease detected. In spite of special care, the mother continued 

 slowly to lose weight and strength and on October 28 was no 

 longer able to sit up. She died that night, seven months after 

 inoculation and four and a half months after delivery. No 

 cough was ever noted, there was no hemorrhage, and as is usual 

 in blastomycosis in the monkey, there was no elevation of tem- 

 perature on the few occasions when this was taken. 



Autopsy. {October 29, 1917). — Autopsy disclosed a chronic 

 pulmonary blastomycosis with cavitation very similar to that 

 seen in man. The lobes of both lungs were adherent to each 

 other, and lesions in adjacent lobes had become continuous in 

 places. The visceral and parietal pleurae were irregularly ad- 

 herent, chiefly in the upper part, though the blastomycosis itself 

 had not extended to them. The cavities were practically of equal 

 extent in both lungs, involving considerable areas and communi- 

 cating with the bronchi. They were lined with gray necrotic 

 material of unpleasant odor. The walls were of variable thick- 

 ness, fibrosed in places, but for the most part actively granulo- 

 matous. 



The other organs presented no perceptible blastomycotic focus. 

 The liver was somewhat fatty, the spleen was a trifle enlarged 

 and slightly congested, and the kidneys showed a fairly marked 

 cloudy swelling. One small inguinal lymph node on the right 

 side, no larger than a small pea, contained a single drop of pus. 



Material from the lungs, in fresh and stained smears and in 

 tissue sections, showed abundant organisms, together with the 

 tissue changes typical of this infection. Cultures were not made, 

 there being no possible doubt as to the identity of the organism. 

 In fresh preparations of material from a cut surface of the 

 spleen occasional blastomycetes were found, though there was 

 no indication of local activity on their part. Preparations from 

 other abdominal viscera were negative for the organisms. A 

 few were found in the pus from the right inguinal lymph node. 



DISCUSSION 



The lesion described was the only instance of chronic pul- 

 monary infection, similar to that found in human cases, that has 

 developed in a total of about 40 monkeys variously inoculated 

 with this organism. In all other instances that have proved 



