300 The Philippine Journal of Science i»is 



to the use of adrenalin for the purpose of dislodging malarial 

 parasites from the internal organs and the fine capillaries. My 

 suggestion passed without comment in the debate. Several other 

 men have since thought of the same thing, have been able to 

 carry it into execution, and have achieved results that, to say 

 the least, are interesting in their bearing on the topic under 

 discussion. 



Neuschlosz(22) has very recently demonstrated that malarial 

 parasites resting in the spleen parenchyma may be made to 

 enter the peripheral circulation through the exhibition of sub- 

 stances believed by some to have the power of causing contrac- 

 tion of the spleen. It may be said in passing that it is yet to 

 be shown that these drugs produce contraction of the spleen. 

 He has used adrenalin, ergot, and extract of hypophysis. The 

 reaction is accompanied by a typical paroxysm and fever, the 

 parasites appearing in the blood from four to six hours after 

 the injection. According to the observations of Neuschlosz, the 

 parasites make their peripheral appearance more promptly after 

 the administration of adrenalin than they do after extract of 

 hypophysis has been given, but with the latter substance they 

 remain in the circulation for a longer period of time. 



Di Pace, (8) working on the same principle, has reported suc- 

 cess following the administration of salts of berberin and of 

 strychnine — preferably the nitrate. 3 



Mandoki and Maule(i9) have used Coci's quinine method in 

 the provocation of blood parasitosis in malaria and were able 

 to detect latent malaria in 50 per cent of the cases thus treated. 

 This test offers the objection, however, that it necessitates the 

 exhibition of the quinine for four weeks. 



Von Draga,(35) in a series of experiments, has succeeded in 

 reviving latent malaria by the injection of sterilized milk. In 

 5 of his cases there was no reaction ; in 13 there was an imme- 

 diate rise of temperature followed, after an interval of ten to 

 fourteen days, by fever and the appearance of the Plasmodia 

 in the blood. In 3 cases he found parasites in the blood, apart 

 from the specific "milk-injection-fever." 



5 The experiments of Di Pace have recently been repeated by King 

 [Indian Journ. Med. Res. (1918), 6, 116], who has failed to confirm the 

 results of Di Pace. King states that strychnine, in most cases, does not 

 bring about an increase in the number of parasites in the peripheral 

 circulation. He concludes that the drug offers no aid in the routine diagnosis 

 of latent malaria. As to the action of strychnine on the spleen, King 

 states that in large doses it brings about a reduction in the size of large 

 spleens, but has no effect on spleens that are only slightly enlarged. 



