xiii, b, 6 Haugkwout : Endemic Malaria 301 



Brauer(2) employed horse serum in his investigations at Sku- 

 tari, Albania. In tropical malaria he witnessed an immediate 

 increase in the number of schizonts and gametocytes. Injec- 

 tions of the serum brought out parasites he had been unable to 

 detect in the blood in some cases, and he therefore employed 

 the method in the detection of latent malaria. Supplementary 

 to other treatment he employed injections of horse serum, fol- 

 lowed in four hours by an intravenous injection of quinine. 

 His use of milk as employed by von Draga was attended with 

 less success. 



Jarno,(l6) on the other hand, reports having tried Brauer's 

 subcutaneous injections of horse serum in 37 cases of malaria, 

 without success. He says nothing about its applicability to the 

 detection of carriers. 



Muller(2l) adds to these provocative methods the irradiation 

 of the spleen with the quartz lamp. 



Reinhard(25) holds that in latent malaria quinine fails, be- 

 cause the parasites are not in the general circulation. There- 

 fore, except in relapses, they are inaccessible to quinine 

 treatment unless first carried into the peripheral circulation. 

 As to the cause of relapses, he ascribes them to a purely mechan- 

 ical factor — the influence of the blood pressure which on eleva- 

 tion would tend to sweep the parasite out of the sinuses and 

 capillaries and into the circulation. This, to say the least, seems 

 quite logical; but at the same time it would seem that other 

 causes as well might bring about the relapses. J. G. Thom- 

 son, (32) in a careful analysis, has finally disposed of Schaudinn's 

 anomalous theory of the parthenogenesis of the macrogameto- 

 cyte. It has long been my belief, (13) first expressed in 1914, 

 that malarial relapses might be induced by a transient hypergly- 

 cemia. Evidence I have since gathered has strengthened that 

 belief and indicates confirmation of the early views of Bass and 

 his coworkers on the influence of blood sugar on the clinical 

 course of malaria. Strikingly suggestive data along these lines 

 has recently been published by de Langen and Schut 6 in their 

 work on tropical acclimatization. 



Reinhard quotes Bach as having shown that irradiation of the 

 spleen with the ultra-violet quartz lamp will bring the parasites 

 into the circulation. Quinine is then given. He adds that still 

 better results than those he cites are obtained by the use of 

 the "aureole lamp" of Siemens and Halske. 



Finally, in connection with the general problem of examination 



•' "Nederl. Tijdschr. voor Geneesk. (1918), 1, 336. 



