xm, b, 6 Haughwout: Endemic Malaria 303 



in each case with a view to detecting any mononucleosis. All 

 positives discovered by this test are to be sent to the hospital 

 for treatment; the cases reported negative by the examiners to 

 be passed on to the 



SECOND STAGE 



This involves the utilization of the provocative methods of 

 the first group I have described; namely, adrenalin, hypophysial 

 extract, ergot, strychnine, 7 berberin, quinine. 



The choice would naturally depend on a study of the com- 

 parative action of the various drugs or upon the individual 

 taste of the military medical officer cooperating in the work. 8 



Positives detected at this stage would be sent to the hospital 

 for treatment, and the negative cases would thereupon pass on 

 to the 



THIRD STAGE 



Here would be used the biological reagents of the second 

 group; namely, milk, horse serum, the quartz lamp. 



Positives finally detected here would, of course, go to the 

 hospital for treatment. The negatives, however, should be kept 

 under medical surveillance for a definite period and watched 

 particularly for symptoms following periods of severe physical 

 exertion, muscular fatigue, or exposure. 



In this paper it is not my purpose to go into the matter of 

 the treatment of malaria. It seems desirable, however, to call 

 attention to a recent very important contribution to malariology. 



Skinner and Carson, (29) working in India in 1911, conceived 

 the idea that irradiation of the spleen by the Roentgen rays 

 might bring about the destruction of malarial parasites lying 

 within the substance of that organ. The authors experimented 

 on eleven cases of malaria, some of them very serious, accom- 

 panied by splenomegaly, and in some cases running a temper- 

 ature of more than 104° F. Some of the cases were admitted 

 to the hospital in collapse. These patients were treated by three- 

 to five-minute exposures to the Roentgen rays. 



7 See footnote 5, p. 300. 



8 1 have recently undertaken a series of studies on the action of these 

 and other drugs, especially with a view to determining, among other 

 things, their effect on the sugar content of the blood. The work is being 

 undertaken in collaboration with some of my colleagues and will include 

 a clinical and pharmacological as well as a protozoological study of the 

 action of the drugs. It is hoped that a preliminary paper may be 

 pubished in the near future. 



156709 2 



