THE PHILIPPINE 



Journal of Science v 



B. Tropical Medicine ^ 



Vol. XII MARCH, 1917 No. 2 



EXPERIMENTAL CHOLERA CARRIERS AND IMMUNITY ^ 



By Otto Schobl and C. S. Panganiban 

 {From the Biological Laboratory, Bureau of Science, Manila, and 

 the Quarantine Laboratory, Health Officer's Department, 

 Port of New York) 



In order to gain some information with regard to the relation 

 between immunity and the state of cholera carriers in experi- 

 mental animals, it was necessary to establish first of all the 

 presence or the absence of immune bodies in the blood of experi- 

 mental cholera carriers, then the presence or the absence of 

 immune bodies in the bile of immunized animals, and finally to 

 study the influence of artificially produced immunity upon the 

 existence and the duration of the state of cholera carriers in ex- 

 perimental animals. 



It has been stated in one of the previous publications (D that 

 immunity has been found to exist as a result of intravesicular 

 inoculation. This question was studied extensively vdth regard 

 to various microbes by Viole. (2) This author found that the 

 serum of rabbits infected by intravesicular injection of various 

 microbes contained immune bodies in the blood and that the con- 

 tent of the infected gall bladder conveyed specific immunity to 

 normal animals. The immunity as produced by intravesicular 

 injection of bacteria is so closely related to the study of cholera 

 carriers that it was deemed advisable to arrange some experi- 

 ments in that direction. 



' Received for publication December 13, 1916. 

 148932 43 



