XII, B, 2 Schobl and Panganiban: Cholera Carriers 49 



It must be admitted that the test is rather severe, because the 

 mode of infection, namely, the introduction of a considerable 

 amount of cholera culture directly into the gall bladder, gives 

 the vibrios the best possible chance to gain a foothold in the 

 gall passages. Again the short time of observation, limited to 

 thirteen days after infection, hardly allows the immunity to 

 develop the maximum of its action. 



CONCLUSIONS 



1. Specific immune bodies were found to be present in the 

 blood serum of experimental cholera carriers (guinea pigs, rab 

 bits). 



2. Specific immune bodies were found to be absent in the 

 normal bile of a highly immunized rabbit. In confirmation of 

 Viole's findings specific antibodies were found to be present in 

 the gall bladder contents of infected rabbits. 



3. The percentage of takes in guinea pigs that received pre- 

 ventive inoculation or vaccine treatment was as high as in un- 

 treated carriers. 



4. Preventive vaccination and vaccine therapy effected no 

 apparent shortening of the duration of cholera carriers in guinea 

 pigs. 



REFERENCES 



(1) Joum. Inf. Dis. (1916), 19, 145. 



(2) Ann. Inst. Pasteur (1912), 26, 147, 381. 



(3) Joum. Inf. Dis. (1916), 18, 307-314. 



