54 The Philippine Journal of Science im 



Schloss and Comniiskey,(46) after investigating the coagula- 

 tion of the blood in 10 cases of the so-called hemorrhagic disease 

 of the newborn, came to the following conclusions : 



1. In the hemorrhagic conditions of the newborn the coagulation of the blood 



may be normal, delayed, or absent. 



2. A deficiency or absence of thrombin or fibrinogen may give rise to im- 



perfect blood coagulation and uncontrollable hemorrhage. 



3. In some cases of hemorrhage in the newborn in which blood coagulation 



is apparently normal, it seems probable that the hemorrhage is due to 

 some localized vascular lesion or defect present only in the areas from 

 which the bleeding occurs. 



4. The subcutaneous injection of whole blood is harmless and is of apparent 



value in the treatment of hemorrhage. 



Shaw and Williams (47) found the coagulation time in infants 

 under 2 years shorter than in adults. 



Tabulating our cases of hemorrhage as to place found in this 

 series of 1,000 autopsies of children under 5 years, we have : 



Hemophilia neonatorum, 2 cases. 



Hemorrhage in the lungs, 9 cases. In one of these the hemor- 

 rhage of the lungs was associated with hemorrhage in the 

 meninges and liver, one with atresia ani, one with acute gas- 

 troduodenitis, and another had also intradural and basal hemor- 

 rhages of the brain. 



Hemorrhage from the navel, 4 cases. Besides the hemorrhage, 

 suppurative thrombophlebitis and bronchopneumonia were found 

 in a 17-day-old infant. 



Cerebellar hemorrhage, 6 cases. It is interesting to note the 

 case of a premature infant that lived for fifty-one days with an 

 old hemorrhage in the cerebellum and tuberculous mesenteric 

 glands and that died of bronchopneumonia. 



Subdural hemorrhage, 7 cases. In 5, atelectasis of the lungs 

 was found ; in 1, bronchopneumonia, icterus, and cirrhosis of the 

 liver, and in the last, meningeal hemorrhage and omphalitis. 



Brain and meningeal hemorrhages, 9 cases. One of these had 

 also umbilical hemorrhage. In a baby 1 month old the hemor- 

 rhage became colliquative, and in another 8 months old it was 

 located in the left parietal region and was organized. 



Meningeal hemorrhage, 16 cases. Atelectasis of the lungs was 

 found in 9, and cephalhematoma was found in 4; both condi- 

 tions were met in 3 cases. The hemorrhage was so extensive 

 in a female 3 months old that the clinicians diagnosed it as 

 eclampsia. 



Fracture of the skull and hemorrhage, 9 cases. One of these 

 had also hemorrhage in the liver. 



