XII, B. 2 Crowell and Johnston: Cholera Cases 93 



cases). Combining these figures it is seen that in 56.2 per cent 

 of the carrier cases vibrios were isolated from the intestine and 

 in 75 per cent from the gall bladder. From these figures we see 

 that in carrier cases, in contrast to what has been shown above 

 in true cholera cases, the vibrios were found in the gall bladder 

 18.8 per cent more frequently than in the intestine. 

 These facts are summarized in Table IV. 



Table IV. — Bacteriologic examination of 32 cholera-carrier cases detected 



post mortem. 



Per cent. 



Intestine + , bile+ 31.2 



Intestine + , bile— 25 



Intestine — , bile+ 43.7 



Intestine + 56.2 



Bile+ 75 



These carrier cases are considered to be of such importance 

 that the main facts concerning them are set forth in Table V. 



CASES KNOWN TO HAVE BEEN CHOLERA CARRIERS 



Five cases which were known to have been cholera carriers 

 have been autopsied. Cholera vibrios had been isolated from the 

 faeces of these cases at periods of thirty-seven to one hundred 

 seventeen days before death. Between the time of isolation of 

 the vibrios and death, from 12 to 24 successive negative exami- 

 nations for the vibrios had been made. 



Careful search was made in these cases for some possible hid- 

 den focus of cholera infection, and numerous cultures from 

 various parts of the body were made. In 4 of these 5 cases no 

 vibrios were found after death. In the fifth case, which had 

 been positive thirty-seven days before death and had since had 

 12 successive negative examinations, a cholera vibrio was isolated 

 from the bile and a nonagglutinable vibrio from the jejunum 

 and upper and lower ileum. Liver, spleen, caecum, and sigmoid 

 showed no vibrios in smears or cultures. This case died of pneu- " 

 monia and a paratyphoid infection. It is to be noted that the 

 interval between the detection of this case as a carrier and his 

 death was the shortest of any of these cases that were examined. 

 Therefore this is the case in which there was the greatest possi- 

 bility of finding the organism. The data concerning these cases 

 arc presented in Table VI. 



