THE PHILIPPINE 



Journal of Science 



B. Tropical Medicine 



Vol. XII SEPTEMBER, 1917 No. 5 



A SURVEY OF CERTAIN CHEMICALS WITH REGARD TO THEIR 

 BACTERICIDAL ACTION ON CHOLERA VIBRIOS WITHIN 

 THE BODY OF EXPERIMENTAL CHOLERA CARRIERS ^ 



By Otto Schobl 



{From the Serum Section of the Biological Laboratory, Bureau of Science, 

 Manila, and the Qiutrantine Laboratory, Health Officers' 

 Department, Port of New York) 



An experimental study of the bactericidal action of drugs upon 

 cholera vibrios in the animal body is of considerable interest. 

 It presents a rational method of searching for a remedy for 

 the cure of cholera carriers and offers a method of testing the 

 value of the so-called intestinal antiseptics. 



Previously published studies on experimental cholera carriers 

 brought to light the following facts. Direct inoculation of 

 cholera culture into the gall bladder is the safest method of 

 producing the state of cholera carriers in experimental 

 animals. (1) A comparatively small amount of cholera culture, 

 injected into the gall bladder, may suffice to produce this con- 

 dition in animals. (2) The virulence of the cholera culture in- 

 creases by being passed from one carrier to another. (3) The 

 condition in question is an inflammation, (4) more or less pro- 

 nounced, of the gall bladder, which under certain circumstances 

 may extend to the liver. No evidence was found to indicate that 

 the infection would extend further so as to assume the septicsemic 

 type. Once the cholera vibrios establish themselves in the gall 

 passages, the bile offering favorable conditions, they multiply 

 therein and are being discharged into the small intestine, where 

 they remain practically without competition. In the large in- 

 testine, due to the presence of numerous other bacteria, the 



* Received for publication May 26, 1917. 

 160681 215 





