220 The Philippine Journal of Science loi? 



No curative effect was noticeable in these experiments (Table 

 II) . The majority of animals died as a consequence of the treat- 

 ment. Autopsy revealed extensive degeneration of the internal 

 organs, particularly of the liver. 



The following chemicals showed an indication of curative 

 effect (Table III) : 



1. Brenzkatechin. One animal treated with this chemical for 

 nine days showed no cholera on direct plates, but cholera vibrios 

 were present in peptone cultures. 



2. Guaiacol. In three of four animals treated with guaiacol 

 there was an effect noticeable. Twice cholera vibros were not 

 found at all in the ileum, while in one case after nine days' treat- 

 ment the cholera vibrios were absent from the entire alimentary 

 tract. 



3. Pyrogalol. First degree effect after nine days' treatment. 



4. Carvacrol. Second degree effect in one animal treated eight 

 days, no effect in one animal treated seven days. Both animals 

 died. 



In this group (Table IV) only turpentine showed a slight 

 effect of the first degree, but the animal died in two days. 



The following chemicals of this group showed an indication of 

 a curative effect (Table VI) : 



1. Antimony tri oxide. Curative effect of first degree in one 

 animal after eight days' treatment. In another animal no effect 

 was noticeable after four days' treatment. 



2. Arsenic trioxide. This chemical, given in large doses, 

 brought about death in two animals treated; in small doses 

 after nine days' treatment by intramuscular injections, complete 

 disappearance of cholera vibrios from the entire alimentary 

 canal. Application by mouth of the same chemical for three days 

 remained without effect in one case. 



3. Atoxyl and sodium cacodylate showed effect of first degree 

 after eight and nine days' treatment, respectively. 



4. Ehrlich-Hata 606. Twelve experimental cholera carriers 

 were treated by intramuscular injections of this drug. Four of 

 them died. In four of the twelve the cholera vibrios have ap- 

 parently disappeared completely during the treatment; in the 

 other two the effect of the first degree was noticeable. 



