256 '^^^ Philippine Journal of Science 



carriers, the importance of species pathogenicity in treatment, 

 and the periodicity of appearance of entamoebas. These are 

 discussed. The experimental treatment of amoebic dysentery 

 with ipecac and its derivatives is reviewed, and particular atten- 

 tion is given to Dobell's successful results with the emetine- 

 bismuth-iodide preparation of Du Mez in amoebic dysentery cases 

 and in amoeba cyst carriers. 



DOES THE IRRITANT ACTION OF EMETINE HYDROCHLORIDE EXTEND 



TO THE KIDNEY? 



By Drs. Daniel de ia Paz and R. Montenegro 



The work was carried out in order to ascertain the irritant 

 effect of hypodermic injection of emetine hydrochloride on the 

 kidney. One milligram per kilogram of dog's weight was in- 

 jected daily. Six dogs were used as controls : two received hypo- 

 dei-mic injection of uranium nitrate, and four received a daily 

 injection of sterile saline solution. The emetinized dogs died 

 with typical symptoms oi emetine poisoning. Emetine caused, 

 in two dogs out of four, ecchymoses at the sites of injection, but 

 in no case did its irritant action extend to the kidneys, although 

 the drug eventually killed the animals. 



R, B. Gibson, 

 Editor of the Proceedings, 



Manila Medical Society. 



