128 "^he Philippine Journal of Science i9i6 



All the pigs had increased in weight at this time to an amount 

 only a little less than that of a single pig, which had been left 

 with the sow. Autopsis of pigs 1 and 2 showed that 

 the animals were seemingly normal. The endocrin glands were 

 well developed. Careful examination of the gums, periostial 

 membranes, and bones gave no evidence of the existence of any 

 scorbutic condition. Histological examination of the sciatic and 

 pneumogastric nerves showed that degenerative changes had 

 taken place ; the sciatic was affected to the greater degree. The 

 sciatic of the fresh-milk-fed pig showed more extensive degen- 

 eration than that of the pig given autoclaved milk, as may be 

 seen from the accompanying reproduction of the microphoto- 

 graphs of the Marchi preparations (Plate II). 



Almost simultaneously on the fifty-sixth day of the experi- 

 ment it was observed that all of the remaining pigs had de- 

 veloped a noticeable oedema of the limbs and face. The pigs, 

 otherwise, were in excellent condition ; they ate well and were 

 growing rapidly. 



Little or no difference could be detected between those receiv- 

 ing the fresh milk and those on the autoclaved milk on the six- 

 tieth day of the experiment. The oedema was still evident. The 

 organs of pigs 3 and 4, which were chloroformed and autopsied, 

 were practically normal. Careful examination gave no evidence 

 of scurvy. The tissues of the limbs were moist from the oedema. 

 The endocrin glands seemed well developed and normal. As 

 in the case of the previous pair of pigs, the sciatic nerves had 

 undergone pronounced degenerative changes; the pneumo- 

 gastrics were much less affected. 



The experiment was continued with the two remaining pigs. 

 These continued to increase in weight rapidly. The oedema 

 of the extremities was intermittently noticeable, and there was 

 a gradually increasing condition of aphonia. On the morning 

 of the seventy-fourth day pig 6 died suddenly. On autopsy 

 much fluid was found in the peritoneal and pleural cavities and 

 the pericardial sack was dilated with clotted blood. Examina- 

 tion of the heart showed that a rupture of the anterior coronary 

 artery had occurred. Otherwise the pig was apparently normal. 

 Examination of the sciatic nerve showed a pronounced degen- 

 eration; the pneumogastric was much less affected. When 

 weighed three days earlier, pigs 5 and 6 weighed 10,700 and 

 11,000 grams, respectively. Pig 5 was found dead on the morning 

 of the one hundred sixth day of the experiment; the body was 

 still warm. Autopsy gave almost the identical picture described 

 for pig 6, the rupture of the coronary vessel occurring in 



