XI, B, 8 Gibson and Concepcion: Development of Neuritis 129 



the apical region and being apparently of longer standing. The 

 heart was elongated with a hypertrophied left ventricle. As 

 with pig 6, there was no evidence of scorbutis. Examina- 

 tion of the sciatic and pneumogastric nerves showed degenerative 

 changes as described for pig 6. 



The experiment with pigs has corroborated the results 

 which we have obtained with fowls and dogs. No effects due 

 to heating the milk have been observed. The results for each 

 pig of each pair have been strikingly similar — ^that is, continued 

 and practically normal growth; no evidence of scorbutic symp- 

 toms; degeneration of the sciatic nerve in every instance and 

 to a less degree of the pneumogastric nerve; oedema in the pair 

 killed at the end of sixty days; and for the remaining pair, 

 oedema, aphonia, and death from rupture of the anterior coronary 

 artery, which had broken through the cardiac musculature. 

 However, we hesitate to attribute the cause of death in these two 

 pigs to the milk diet without further experimental confirmation. 



GROWTH OF DOGS AND PIGS FED ON FRESH AND ON AUTOCLAVED 



cows' MILK 



The literature on the effects of boiled milk on the development 

 of young animals has been reviewed by Lane-Clapon.^^ She con- 

 cludes that animals and infants develop better on milk of their 

 own species, whether this milk is boiled or raw; that on milk 

 of foreign species development is best on boiled milk; and that 

 it is by no means proved that infants develop scurvy from 

 boiled milk alone. We shall discuss our results briefly in the 

 light of later investigations of conditions which influence groAvth. 



Recent experimental work has indicated that growth processes 

 are stimulated by accessory nutritive principles contained in the 

 food. Young animals fed on artificial mixtures of pure salts, 

 carbohydrates, fats, and complete proteins do not grow. Hop- 

 kins ^- has shown that the addition of small amounts of milk 

 to such a diet leads to immediate and normal growth. Funk ^^ 

 has reported that young chickens fed on unpolished rice similarly 

 do not increase in size; unpublished experiments on young 

 chickens and rabbits have led us to the same conclusion. Os- 

 borne and Mendel " have shown that the growth principle in 

 cows' milk for rats is associated with the milk fats and occurs 



'^ Ergebn. d. inn. Med. u. Kinderh. (1913), 635; Report to the Local 

 Government Board, London (1912), n. s. No. 63, 1219. 

 " J oum. Physiol. (1912), 44, 425. 

 '^ Zeitschr. f. physiol. Chem. (1914), 88, 352. 

 "Joum. Biol. Chem. (1915), 20, 379. 



