LLLuSTRATiOIvlfe 



Plate I 



Fig. 1. Numerous small lesions on back, with one framboesial nodule. 



2. Showing the deep infiltration of the lobe of the ear and the verrucous 



lesion of the margin. 



3. Closer view (slightly larger than natural) of nodule in fig. 1. 



4. External surface of right arm, showing numerous active lesions and 



edge of an extensive scar on the posterior surface. 



5. Extensive keloidal cicatrix on left elbow. An active lesion later 



developed at the point indicated. 



Plate II 



Fig. 6. Low magnification of granulomatous tissue from a typical active 

 nodule, after Mallory's connective-tissue stain. The more active 

 lesions under the epidermis photograph black because of great 

 numbers of fuchsin-stained erythrocytes. X 25. 



7. A moderately active focus, showing accumulation of various cells 



and the prominence of vascular spaces. Delafield's hasmatoxylin 

 and eosin. X 125. 



8. A group of basic forms apparently recently liberated. In the lower 



left corner is a half-grown parasite with loose protoplasm. 

 X 1000. 



9. Shows an indefinitely outlined phagocyte above and one free in a 



blood space below. Numerous free parasites are also present. 

 In the lower right corner is a nude body (basic form). The arrow 

 indicates a probable form which resembles a plasma cell. X 1000. 



10. A phagocyte containing normal and degenerated parasites. Above 



is a parasite which has become irregularly outlined, apparently 

 in preparation for subdivision. X 1000. 



11. From smear of tissue scrapings. Two endothelial phagocjrtes con- 



taining numerous typical basic parasitic forms. One larger, free 

 parasite also present. Giemsa's stain. X 1000. 



12. A similar phagocyte with five basic forms. From the same prepara- 



tion as fig. 11. 



Plate III 



Fig. 13. An active focus illustrating the invasion of the epidermis by the 

 infection. Many of the cells that resemble leucocytes are possibly 

 parasites. The condition of the erythrocytes indicates direct 

 connection with the blood channel in the chorium. A granule is 

 budding off of the parasite (?) indicated. Ehrlich's iron hsema- 

 toxylin stain. X 450. 

 14. Showing several parasites in various stages. A number of round 

 forms, with and without protoplasm, are scattered throughout the 

 preparation. At a a large parasite has segmented to produce 

 basic parasitic forms, and at b are a number of these forms 

 recently liberated. X 450. 



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